Danny Hsu: Aspirin May Prevent Cancer Metastases?
Danny Hsu, President of THANZ, reposted from NEJM Group on LinkedIn:
”This is so awesome.
Aspirin may prevent cancer metastases????…when platelets intersects with malignancy
Annnnnnnnd that’s why we thrombosis/haemostasis folk LOVE platelets!!”
Quoting NEJM Group‘s post:
”A new study shows that aspirin enhances antimetastatic immunity by decreasing platelet activation, thereby releasing T cells from suppression by thromboxane A2.
The effects of aspirin on cancer metastasis were first recognized more than 50 years ago. In a seminal study, Gasic and colleagues found that fewer lung metastases developed in mice whose drinking water was supplemented with aspirin than in control mice.
Epidemiologic data support the hypothesis that aspirin prevents cancer, but the design and interpretation of randomized trials have been hampered by a lack of mechanistic understanding.
This is changing. In a recent report, Yang and colleagues describe a previously unrecognized immunosuppressive mechanism that prevents T cells from eliminating cancer metastases.
At the heart of this prometastatic mechanism is a protein called ARHGEF1, which is activated by thromboxane A2 (TXA2), a metabolite of the platelet arachidonic acid pathway.
This pathway is inhibited by aspirin through inactivation of cyclooxygenase (COX) enzymes.
Learn more in the Clinical Implications of Basic Research article “Understanding How Aspirin Prevents Metastasis” by Ruth E. Langley, MB, BS, PhD, and John Burn, MD, from UCL and Newcastle University.”
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