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Danny Hsu: Rethinking Bleeding Risk in Patients on Anticoagulation
Danny Hsu/LinkedIn, Debora Siegal/LinkedIn
Aug 24, 2026, 14:58

Danny Hsu: Rethinking Bleeding Risk in Patients on Anticoagulation

Danny Hsu, President of THANZ, Director of Therapeutic Apheresis, Immune and Obstetric Haematology at South Western Sydney Local Health District, shared Deborah Siegal‘s post on LinkedIn, adding:

“Excellent study by Deborah Siegal et al regarding the incidence and predictors of extracranial bleeding on OAC in AF patients!!!”

Deborah Siegal, Associate Professor, Department of Medicine at University of Ottawa, shared a post on LinkedIn about a recent article she and her colleagues co-authored, published in Circulation journal, adding:

“Newly published in Circulation

Bleeding remains the major complication of oral anticoagulation, but are we focusing on the right bleeding outcome?

In this Combine – AF individual patient meta-analysis of 73,737 patients, we found:

  • 1 in 4 patients experienced clinically relevant extracranial bleeding over approximately 2 years.
  • Clinically relevant non-major bleeding accounted for the majority of bleeding events.
  • Low hemoglobin, impaired kidney function, prior stroke, cancer and Asian ancestry were among the strongest predictors.
  • Known risk factors explained only approximately 2/3 of bleeding risk, far less than for stroke or MI, underscoring the need for novel predictors.

The next step: understanding what these bleeds actually mean for patients!

Huge thanks to collaborators Marc Carrier, M Cecilia Bahit, Alexander Benz, Jackie Bosch, Brian Bergmark, Bob Giugliano, Chris Granger, Victorien Monguillon, Martin O’Donnell, Manesh Patel, Jonas Oldgren, Rohin Reddy, Lars Wallentin, Qilong Yi, André Zimerman, John Eikelboom.”

Title: Incidence and Predictors of Extracranial Bleeding on Oral Anticoagulants for Stroke Prevention in Patients With Atrial Fibrillation: A Combine-AF Analysis

Authors: Deborah M. Siegal, Marc Carrier, M. Cecilia Bahit, Jackie Bosch, Alexander P. Benz, Brian Bergmark, Robert P. Giugliano, Christopher B. Granger, Victorien Monguillon, Martin O’Donnell, Jonas Oldgren, Manesh R. Patel, Rohin K. Reddy, Lars Wallentin, Qilong Yi, Andre Zimerman, John Eikelboom

Danny Hsu, Deborah Siegal

Other posts featuring Danny Hsu and Deborah Siegal on Hemostasis Today.

 

AHA Journals Alexander P. Benz Andre Zimerman Anticoagulation bleeding disorders Blood Brian Bergmark Cardiology Christopher B. Granger Circulation Journal Danny Hsu Deborah M. Siegal Health Hematology Hemostasis Hemostasis News Hemostasis Today Jackie Bosch John Eikelboom Jonas Oldgren Lars Wallentin M. Cecilia Bahit Manesh   R. Patel Marc Carrier Martin O'Donnell Medicine Qilong Yi Robert P. Giugliano Rohin K. Reddy Victorien Monguillon
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