Dimpy Modi: Pilot Trial Protocol Investigates Liberal vs. Restrictive Red Blood Cell Transfusion in Leukemia
Dimpy Modi, Medical Affairs Lead of Critical Care and Hematology at Octapharma, shared a post on LinkedIn about a recent article she and her colleagues co-authored, published in Pilot and Feasibility Studies, adding:
“Our protocol for a pilot randomized controlled trial of liberal versus restrictive red cell transfusion in leukemia is now published online in Pilot and Feasibility Studies!
Link to the paper here.
Most transfusion trials try to evaluate how low hemoglobin can safely go. In leukemia, there’s another question that hasn’t had much attention.
Patients are often anemic and thrombocytopenic at the same time, and RBCs play a role in helping move platelets along the vessel wall. So if we transfuse RBCs more conservatively, could that affect bleeding outcomes in patients who are already low on platelets?
This trial design was the core of my PhD thesis work, and I’m excited to share it.
Thank you to everyone on the study team!”
Title: Liberal versus restrictive red blood cell transfusion strategies in leukemia: protocol for a pilot randomized controlled trial using bleeding-related biomarker endpoints
Authors: Dimpy Modi, Tobias Berg, Erin Jamula, Nancy Heddle, Dongyoung Kim, Patricia C. Liaw, Yang Liu, Melissa J. Parker, Geoff Travis, Kathryn E. Webert, Donald M. Arnold
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