Emma Lefrancais: Uncovering A Key Role for The IL-33/ST2 Axis in Platelet Biology with Lucie Gelon
Emma Lefrancais, Scientific Researcher at CNRS, shared on LinkedIn about a recent article by Lucie Gelon et al, published in Blood Advances:
”I’m delighted to share the publication of Lucie Gelon PhD work, available online at Blood Advances, uncovering a key role for the IL-33/ST2 axis in platelet biology:
‘The alarmin Interleukin-33 modulates platelet proteome, function and biogenesis’
Although platelets do not express IL-33, our study shows that IL-33 profoundly shapes their production and function.
We demonstrate that IL-33/ST2 signaling:
- remodels the platelet proteome, enriching inflammatory proteins
- impairs platelet adhesion and thrombus formation when absent
- accelerates platelet production in the lung by promoting megakaryocyte fragmentation within the vasculature
These mechanisms are likely to be particularly relevant during stress and aging, when IL-33–responsive megakaryocyte precursors expand.
Huge congratulations to Lucie Gelon for this great work at IPBS-Toulouse (CNRS-UT3), and many thanks to all co-authors and collaborators, Stéphane Roga, Jean-Philippe Girard, Anne Gonzalez de Peredo, Edith Vidal and Sonia Severin!”
Title: The alarmin Interleukin-33 modulates platelet proteome, function and biogenesis
Authors: Lucie Gelon, Stéphane Roga, Anne Gonzalez-de-Peredo, Edith Vidal, Jean-Philippe Girard, Sonia Severin, Emma Lefrançais
Read the Full Article on Blood Advances
Stay updated on all scientific advances with Hemostasis Today.
-
Apr 11, 2026, 13:51David McIntosh: Vital Plasma Derived Medicines – The Anomalous UK Scene
-
Apr 11, 2026, 13:47Samrawit Terefe: O Negative Blood Is the Universal Donor With Extreme Scarcity
-
Apr 11, 2026, 13:39Dheeraj Garg: Rethinking Cardiovascular Disease – A Cardiologist’s Perspective
-
Apr 11, 2026, 13:37Kushal Bhatia: Is The 4.5-Hour Thrombolysis Window Officially Outdated?
-
Apr 11, 2026, 13:35William Aird: Why Did Mammalian Red Blood Cells Give Up Their Nucleus?
-
Apr 11, 2026, 13:30Ken Kuang: Gravity Is Constant, But Your Vein Health Doesn’t Have to Be
-
Apr 11, 2026, 13:21Mascha Kern: Measuring Gender’s Role in Stroke and Migraine
-
Apr 11, 2026, 13:10Danique Steeghs: Key Findings from a Microfluidic Chemiluminescent Thrombin Generation Assay
-
Apr 11, 2026, 13:06Shanvi Mahi: A Validated Tool to Explore Lived Experiences After Stroke Rehabilitation