Eric Topol: Anti-H2B Autoantibodies Linked to Aortic Calcification in Atherosclerosis
Eric Topol, Founder and Director of Scripps Research Translational Institute, shared a post on X about a recent article by Chuankai Zhang et al, published in Nature Cardiovascular Research, adding:
“Evidence for lymph node organs in unsuspected places of the body keeps emerging.
Now with the artery to promote autoimmunity and accelerate atherosclerosis.
An auto-antibody titer (anti-H2B) predicts thoracic artery calcification in people, at least as well as LDL cholesterol.”
Title: Artery tertiary lymphoid organs encode a pathogenic high-affinity autoantibody−autoantigen pair in atherosclerosis
Authors: Chuankai Zhang, Xi Zhang, Yi Ran, Zhihua Wang, Liping Li, Shu Wang, Junjie Zheng, Yixin Zhang, Ting Sun, Yutao Li, Shu Lu, Mingyang Hong, Zhe Ma, Sabine Steffens, Michael Hristov, Xavier Blanchet, Jingpu Zhu, Xinwen Dou, Xinyi Deng, Klaus Dornmair, Desheng Hu, Shibojyoti Lahiri, Axel Imhof, Nadja Sachs, Lars Maegdefessel, Jingyi Xiao, Jianning Zhang, Yan Wang, Hua Hong, Livia Habenicht, Xinyu Weng, Junbo Ge, Christian Weber, Donato Santovito, Rachael Bashford-Rogers, Sarajo K. Mohanta, Klaus Ley, Andreas J. R. Habenicht, Changjun Yin
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