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Fibrinogen αC Domain Lysines Drive Plasminogen Binding and Plasmin Generation – JTH
First author of the article - Ali Aftabjahani/LinkedIn
May 25, 2026, 05:04

Fibrinogen αC Domain Lysines Drive Plasminogen Binding and Plasmin Generation – JTH

Journal of Thrombosis and Haemostasis (JTH) shared on LinkedIn about a recent article by Ali Aftabjahani et al, adding:

”The Fibrinogen αC Domain Binds Plasminogen and Enhances Plasmin Generation on Thrombin-Activated Platelets

This study reveals that C-terminal lysine residues in fibrinogen’s αC domain are critical for maximal plasminogen binding and plasmin generation on activated platelets, a process suppressible by TAFIa.”

Title: The Fibrinogen αC Domain Binds Plasminogen and Enhances Plasmin Generation on Thrombin-Activated Platelets

Authors: Ali Aftabjahani, Chengliang (Chris) Wu, Matthew Flick, Peter Gross, Paul Kim

Fibrinogen αC Domain Lysines Drive Plasminogen Binding and Plasmin Generation - JTH

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C-terminal lysine Fibrinogen αC Health Hematology Hemostasis Hemostasis News Hemostasis Today JTH Medicine Plasmin Generation Plasminogen Binding TAFIa thrombosis
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