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Hisam Siddiqi: Revisiting the Classic List of Risk Factors for Venous Thromboembolism
Hisam Siddiqi/LinkedIn
May 18, 2026, 04:41

Hisam Siddiqi: Revisiting the Classic List of Risk Factors for Venous Thromboembolism

Hisam Siddiqi, Consultant Haematologist at LycaHealth, The Blackheath Hospital, Dartford and Gravesham NHS Trust, shared a post on LinkedIn:

”Rethinking VTE Risk Factors – Beyond the Checklist

I recently revisited the classic list of risk factors for venous thromboembolism (VTE) — but this time, with practical, real-world reflections added.
A few key takeaways from my annotations:

Not all thrombophilia tests are equal
Factor V Leiden and Prothrombin mutations are common but often over-interpreted.

They rarely dictate long-term anticoagulation decisions in isolation.

Focus on what truly matters
Protein C, Protein S, and Antithrombin deficiencies remain clinically meaningful and should be part of a thoughtful thrombophilia screen.

Always think acquired causes
Antiphospholipid syndrome, malignancy, inflammation, immobility — these often carry greater weight than inherited risks.

Don’t miss the basics

  • Line-associated thrombosis – often preventable with good care
  • Surgery risk persists up to 90 days
  • Always ask about COCP in young patients
  • Obesity plus immobility equals underestimated contributors

Look deeper when indicated

  • Consider MPNs – check JAK2 / CALR / MPL
  • Nephrotic syndrome – think antithrombin loss
  • Unprovoked VTE – screen for underlying malignancy appropriately

Context is everything Risk factors don’t act in isolation — it is the combination, timing, and clinical scenario that should guide decision-making.

Teaching point:
Thrombosis is rarely explained by a single lab result.

Clinical judgement remains the most powerful tool we have.”

Hisam Siddiqi: Revisiting the Classic List of Risk Factors for Venous Thromboembolism

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