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Ayesha Zia and Taem: New ISTH Guidance for Pediatric PE Outcomes
Ayesha Zia, MD, MSCS/LinkedIn
Dec 23, 2025, 23:01

Ayesha Zia and Taem: New ISTH Guidance for Pediatric PE Outcomes

Ayesha Zia, Professor of Pediatrics, Associate Division Chief, Clinical Sciences Research, Pediatric Hematology-Oncology at UT Southwestern Medical Center, posted on LinkedIn:

”If you conduct pediatric Pulmonary Embolism (PE) research, our recent International Society on Thrombosis and Haemostasis (ISTH) SSC communication on research outcomes in pediatric PE should guide your outcome selection. It reflects two years of careful, multidisciplinary, evidence-informed consensus from experts with deep PE expertise.

In this document, we propose clinically relevant outcomes, standardized definitions, and recommended timing of assessment for:

  • mortality
  • bleeding
  • recurrence
  • post-PE syndrome
  • endovascular therapy outcomes
  • patient-reported outcomes, and
  • healthcare utilization

It also provides pediatric-specific considerations for imaging, echocardiography, and cardiopulmonary exercise testing, emphasizing alignment with existing frameworks.

Together, this work provides a foundation for more rigorous, comparable, and patient-centered PE research and Clinical Trials as the field continues to grow.

Grateful to my co-authors for their collaboration.

Now out in Journal of Thrombosis and Haemostasis (JTH).”

Title: Clinically relevant outcomes for research in pediatric pulmonary embolism: communication from the ISTH SSC Subcommittee on Pediatric/Neonatal Thrombosis and Hemostasis

Authors: Ayesha Zia, Hilary Whitworth, Laura Avila, Frederikus A. Klok, Manal Alqahtani, Deepa Gopalan, Megan Griffiths, Rachel P. Rosovsky, Suzan Williams, Tony G. Babb, Madhvi Rajpurkar

ISTH

 

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Ayesha Zia clinical trials deep vein thrombosis Deepa Gopalan DVT Frederikus A Klok Headlines Health Hematology Hemostasis Hemostasis Today Hilary Whitworth International Society on Thrombosis and Haemostasis ISTH ISTH SSC Journal of Thrombosis and Haemostasis JTH Laura Avila Madhvi Rajpurkar Manal Alqahtani Medicine Megan Griffiths PE Pediatric PE Pediatric Pulmonary Embolism Pulmonary embolism Rachel P. Rosovsky research Suzan Williams thrombosis Tony G. Babb UT Southwestern Medical Center
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