Sam Tsimikas: Lp(a) and Oxidized Phospholipids Reveal a New Link Between Hypercoagulability and Stronger Clot Formation
Sam Tsimikas, Professor of Medicine at the University of California, San Diego, shared a post on X about a recent article by Paul A. Gurbel et al, published in AHAIASA Journals, adding:
“The story of Lp(a) and oxidized phospholipids (OxPL) continues to expand, beyond atherosclerosis and inflammation, and now into clot formation and clot strength.
In our new study in ATVB, Lp(a), OxPL-apoB and other OxPL biomarkers were linked to hypercoagulability and increased tensile clot strength, providing another potential mechanism into how Lp(a) may contribute to atherothrombotic risk.
Particularly intriguing is the connection between Lp(a), oxidized phospholipids (OxPL), coagulation and fibrinolysis, and the formation of stronger clots, and what this may mean as potent Lp(a)-lowering therapies move toward clinical practice.
Many thanks to my terrific co-authors and collaborators Paul Gurbel, Udaya Tantry, Kevin Bliden, William Ashley, and Young Hoon Jeong for making this work possible.
The biology of Lp(a) keeps getting more interesting.”
Title: Lipoprotein(a), Oxidized Phospholipids and Tensile Clot Strength Measured by Thromboelastography in Patients Undergoing Percutaneous Intervention
Authors: Paul A. Gurbel, Udaya S. Tantry, Kevin P. Bliden, William W. Ashley, Young Hoon Jeong, Sotirios Tsimikas
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