Jim Hoffman: Targeting Extracorporeal Removal of Extracellular Chromatin to Mitigate Lupus Pathogenesis
Jim Hoffman, Former Technical Advisor at Cygnus Technologies, LLC, posted on LinkedIn about a recent article by Neelakshi R. Jog et al, published in Wiley Online Library:
“Older, but highly relevant, translational evidence is provided by Jog et al, suggesting we should be targeting extracorporeal removal of extracellular chromatin as a therapy to help mitigate the pathogenesis of lupus-like diseases, where nuclear chromatin and NETs are known to be chronically elevated and apoptotic cell body clearance is insufficient, and efferocytosis is impaired.
Particularly, when normal basal levels of nuclear chromatin/NETs remain persistently elevated extracellularly in the blood, other body fluids, and tissues in response to infectious and non-infectious disease triggers.
Caspase-activated DNase is required for maintenance of tolerance to lupus nuclear autoantigens.
‘In accordance with findings in the CAD-mutant Sle1 and Sle123 mice, CAD-deficient 3H9 mice spontaneously generated anti-DNA antibodies. Finally, we showed that autoantibodies with specificities toward histone-DNA complexes bind more to CAD-deficient apoptotic cells than to CAD-sufficient apoptotic cells.’
‘These results strongly suggest that in mice genetically predisposed to autoimmunity, the absence of chromatin fragmentation and the resulting abnormal display of apoptotic AutoAgs, result in failure to achieve anergy and instead promote B cell autoreactivity.'”
Title: Caspase-activated DNase is required for maintenance of tolerance to lupus nuclear autoantigens
Authors: Neelakshi R. Jog, Lorenza Frisoni, Qin Shi, Marc Monestier, Sairy Hernandez, Joe Craft, Eline T. Luning Prak, Roberto Caricchio
Read the Full Article on Wiley Online Library.
Get the latest from Hemostasis Today.
-
Apr 18, 2026, 15:36Robert Hamilton: A Candid Conversation with Leading Stroke Experts on the Future of Stroke Care
-
Apr 18, 2026, 15:24Jeyaraj Pandian: Stroke Is No Longer an Inevitable Sentence to Death or Lifelong Disability
-
Apr 18, 2026, 15:24Megan Adediran: World Haemophilia Day Is More Than a Date on the Calendar
-
Apr 18, 2026, 15:10Owen McCarty։ Honored to Deliver the Bell Lectureship at Johns Hopkins University
-
Apr 18, 2026, 15:04Rene Staebe: Dare to Care in Hemophilia – When Small Acts Change Lives
-
Apr 18, 2026, 14:31Abeer Alanazi: New Stroke Prevention Without Increased Bleeding Risk
-
Apr 18, 2026, 14:28Krishnakant Prasad: Hemodynamic Stress and Arterial Wall Integrity in Aneurysm Formation
-
Apr 18, 2026, 13:57Arwa Z. Al-Riyami: Shaping the Future of Transfusion Medicine Through Artificial Intelligence
-
Apr 18, 2026, 13:37Bridget Flynn: An Opportunity to Support Medication Management for Stroke Survivors