Jim Hoffman: NETosis Dysregulation Links Cancer Progression and Autoimmunity
Jim Hoffman, Former Technical Advisor at Cygnus Technologies, LLC, posted on LinkedIn:
“‘These findings suggest that germline-encoded anti-NMDAR antibodies contribute to immune surveillance but can also trigger autoimmune disease after maturation, revealing a mechanistic trade-off between cancer immunity and neurotoxicity.’ Janowitz et al 2026
Can extracorporeal NET removal therapy help keep both cancer progression and anti-NMDR autoimmunity in remission by improving innate immune system macrophage-mediated phagocytosis/efferocytosis that is likely compromised by having too many NETs and extracellular chromatin in the blood circulation?
Cancer progression and anti-NMDR autoimmunity have both been shown to result in NETosis dysregulation (hyper-NET induction and impaired NET clearance) that positively correlates with the severity of both diseases.
NETosis: A bridge between cancer and autoimmunity
‘Cancer and autoimmunity crosstalk have been well-established. Cancer-induced autoimmunity is associated with the onset of several autoimmune disorders, including rheumatic diseases and paraneoplastic cerebellar degeneration, among others.’
Neutrophil extracellular traps: New players in cancer research
Reviewed by Jin et al 2022
The plasma’s obtained from Anti-NMDA receptor patients exacerbates NETosis dysregulation, NETosis induction, and these patients also demonstrate impaired NET clearance.
CD47 blockade ameliorates autoimmune vasculitis via efferocytosis of neutrophil extracellular traps”
Title: NETosis: A bridge between cancer and autoimmunity
Authors: Niloufar Orooji, Manouchehr Fadaee
Read the Full Article on Rheumatology and Autoimmunity
Title: Neutrophil extracellular traps: New players in cancer research
Authors: Junjie Zhao, Jiaqi Jin
Read the Full Article on Frontiers in Immunology
Title: Increased formation of neutrophil extracellular traps in patients with anti-N-methyl-d-aspartate receptor encephalitis
Authors: Shan Qiao, Quan-ye Sun, Peng Zhou, Shan-chao Zhang, Zhi-hao Wang, Hai-yun Li, Ai-hua Wang, Xue-wu Liu, Tao Xin
Read the Full Article on Frontiers in Immunology
Title: CD47 blockade ameliorates autoimmune vasculitis via efferocytosis of neutrophil extracellular traps
Authors: Satoka Shiratori-Aso, Daigo Nakazawa, Takashi Kudo, Masatoshi Kanda, Yusho Ueda, Kanako Watanabe-Kusunoki, Saori Nishio, Sari Iwasaki, Takahiro Tsuji, Sakiko Masuda, Utano Tomaru, Akihiro Ishizu, Tatsuya Atsumi
Read the Full Article on JCI Insight
Title: Ectopic NMDAR expression in cancer unmasks germline-encoded autoimmunity
Authors: Sam O. Kleeman, Kevin Michalski, Xiang Zhao, Ruben Steigerwald, Miriam Ferrer, Llewelyn Levett, Ethan Ertel, Austin Schultz, Noriko Simorowski, Pamela Moody, Tse-Luen Wee, Cristina Valente, Sharon Fox, Mateusz Makuch, Selina Thomsen, Ruby Harrison, Claire Regan, Jonathan Preall, Qing Gao, Dennis Thomas, Jill Habel, Rachel Rubino, Sarosh Irani, Hiro Furukawa, Tobias Janowitz
Read the Full Article on Nature
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