Jim Hoffman: Targeting NETosis to Restore Immune Homeostasis
Jim Hoffman, Former Technical Advisor at Cygnus Technologies, LLC, shared a post on LinkedIn:
“True, but we still need better therapies for all 3 circumstances: infections in the unvaccinated, post-vaccination breakthrough infections, and the smaller number of serious adverse reactions due to vaccine-related side effects.
We should try targeting NETosis dysregulation in response to all three. This extracorporeal therapy is performing well in case study treatments of advanced drug-refractory autoimmune disease.
We should see if it can help avert serious autoimmune disease, septic shock and promote recovery from unwanted symptoms sooner than standard treatments.
In addition to vaccination protection, which is designed and tested for efficacy in minimizing morbidity and mortality, we still need to investigate better therapies that offer hope of restoring immune system homeostasis in response to infections, regardless of vaccination status.
This NET removal therapy which I have been tracking and advocating for, should be tried for anyone having difficulty recovering from an infectious insult and a potential adverse response to vaccination.
Excessive and persistent NETosis induction and, more importantly, poor NET clearance are universal hallmarks of serious acute and post-infection chronic illness. (e.g Long Covid).
Removing hyperactivated NETs from the blood of lupus patients has recently been demonstrated to help restore immune system homeostasis in severe drug-refractory lupus.
Why not try this specific NET removal therapy for sick patients struggling to recover from an infectious insult or a serious adverse vaccination response?
Neutrophil extracellular traps in influenza infection
NETosis: A key player in autoimmunity, COVID-19, and long COVID
Impaired balance between neutrophil extracellular trap formation and degradation by DNases in COVID-19 disease
Neutrophil Extracellular Traps That Are Not Degraded in Systemic Lupus Erythematosus Activate Complement Exacerbating the Disease
Elevated NETs and Calprotectin Levels after ChAdOx1 nCoV-19 Vaccination Correlate with the Severity of Side Effects
NETosis induction reflects COVID-19 severity and long COVID: insights from a 2-center patient cohort study in Israel
Circulating Markers of Neutrophil Extracellular Traps Are of Prognostic Value in Patients With COVID-19
Persistence of neutrophil extracellular traps and anticardiolipin auto-antibodies in post-acute phase COVID-19 patients
A Novel Assay for Neutrophil Extracellular Trap Formation Independently Predicts Disseminated Intravascular Coagulation and Mortality in Critically Ill Patients”
Title: Neutrophil extracellular traps in influenza infection
Authors: Alireza Zafarani, Mohammad Hossein Razizadeh, Atousa Haghi
Title: NETosis: A key player in autoimmunity, COVID-19, and long COVID
Authors: Diana M Monsalve, Yeny Acosta-Ampudia, Nicolás Guerrero Acosta, Mariana Celis-Andrade, Ali Şahin, Ahsen Morva Yilmaz, Yehuda Shoenfeld, Carolina Ramírez-Santana
Title: Impaired balance between neutrophil extracellular trap formation and degradation by DNases in COVID-19 disease
Authors: Geoffrey Garcia, Sylvie Labrouche-Colomer, Alexandre Duvignaud, Etienne Clequin, Charles Dussiau, David-Alexandre Trégouët, Denis Malvy, Renaud Prevel, Atika Zouine, Isabelle Pellegrin, Julien Goret, Maria Mamani-Matsuda, Antoine Dewitte, Chloe James
Title: Neutrophil Extracellular Traps That Are Not Degraded in Systemic Lupus Erythematosus Activate Complement Exacerbating the Disease
Authors: Jonatan Leffler, Myriam Martin, Birgitta Gullstrand, Helena Tydén, Christian Lood, Lennart Truedsson, Anders A. Bengtsson, Anna M. Blom
Title: Elevated NETs and Calprotectin Levels after ChAdOx1 nCoV-19 Vaccination Correlate with the Severity of Side Effects
Authors: Geir Hetland, Magne Kristoffer Fagerhol, Markus Karl Hermann Wiedmann, Arne Vasli Lund Søraas, Mohammad Reza Mirlashari, Lise Sofie Haug Nissen-Meyer, Mette Stausland Istre, Pål Andre Holme, Nina Haagenrud Schultz
Title: NETosis induction reflects COVID-19 severity and long COVID: insights from a 2-center patient cohort study in Israel
Authors: Nitzan Krinsky, Sofia Sizikov, Sivan Nissim, Adi Dror, Anna Sas, Hodaya Prinz, Ester Pri-Or, Shay Perek, Ayelet Raz-Pasteur, Izabella Lejbkowicz, Sivan Ida Cohen-Matsliah, Ronit Almog, Nikanor Chen, Ramzi Kurd, Amir Jarjou’i, Ariel Rokach, Eli Ben-Chetrit, Avi Schroeder, Aleah F. Caulin, Christian Con Yost, Joshua D. Schiffman, Mor Goldfeder, Kimberly Martinod
Title: Circulating Markers of Neutrophil Extracellular Traps Are of Prognostic Value in Patients With COVID-19
Authors: Henry Ng, Sebastian Havervall, Axel Rosell, Katherina Aguilera, Kristel Parv, Fien A. von Meijenfeldt, Ton Lisman, Nigel Mackman, Charlotte Thålin, Mia Phillipson
Title: Persistence of neutrophil extracellular traps and anticardiolipin auto-antibodies in post-acute phase COVID-19 patients
Authors: Ekaterina Pisareva, Stephanie Badiou, Lucia Mihalovičová, Alexia Mirandola, Brice Pastor, Andrei Kudriavtsev, Marie Berger, Camille Roubille, Pierre Fesler, Kada Klouche, Jean-Paul Cristol, Alain R. Thierry
Title: A Novel Assay for Neutrophil Extracellular Trap Formation Independently Predicts Disseminated Intravascular Coagulation and Mortality in Critically Ill Patients
Authors: Simon T. Abrams, Ben Morton, Yasir Alhamdi, Mohmad Alsabani, Steven Lane, Ingeborg D. Welters, Guozheng Wang, Cheng-Hock Toh
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