A Plasma Proteomic Signature of Antiphospholipid Syndrome – JTH
Journal of Thrombosis and Haemostasis (JTH) shared a post on LinkedIn about a recent article by Dagmar van Mourik et al, adding:
“Plasma protein profile in patients with antiphospholipid syndrome and controls without antiphospholipid syndrome.
The study used two cohorts: a discovery cohort (61 APS patients versus 19 controls) and a verification cohort (77 versus 49).
Quantitative mass spectrometry of 159 plasma proteins found six proteins that differed consistently in clinically stable APS: alpha-1-acid glycoprotein 1, β2-microglobulin, complement C2, IGFALS, LRG1 and cystatin-C.
The authors suggest these point to subclinical inflammation and renal involvement.”
Title: Plasma protein profile in patients with antiphospholipid syndrome and controls without antiphospholipid syndrome
Authors: Dagmar J.M. van Mourik, Britte F. van der Vliet, Dorien Salet, L. Renee Ruhaak, Natasja Dolezal, Jan Wouter Drijfhout, Robert A. Cordfunke, Astrid van Hylckama Vlieg, Frederikus A. Klok, Michiel Coppens, Mettine H.A. Bos, Saskia Middeldorp, Jeroen C.J. Eikenboom, Bart J.M. van Vlijmen, Thijs E. van Mens
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