Lakmali Silva: Fibrinolysis and Its Role in Hematopoietic Recovery After Chemotherapy
Lakmali Silva, Assistant Professor at Harvard School of Dental Medicine, shared a post on LinkedIn about a recent article she and her colleges co-authored, published in Blood Advances, adding:
“Excited to share our newly published work in Blood Advances: ‘Plasmin-mediated fibrinolysis plays a critical role in hematopoietic recovery after 5-FU-mediated myeloablation.’
We show that fibrin accumulates in the bone marrow following chemotherapy-induced myeloablation and that its timely clearance is critical for hematopoietic recovery.
When fibrinolysis is impaired, persistent fibrin limits marrow regeneration—an effect that can be rescued by reducing fibrinogen or disrupting fibrin engagement with the myeloid integrin αMβ2.
These findings identify fibrin not simply as a consequence of tissue injury, but as an active regulator of hematopoietic regeneration.
Very proud of the team and everyone who contributed to this work!”
Title: Plasmin-mediated fibrinolysis is required for hematopoietic recovery after 5-FU–induced myeloablation
Authors: Tiffany P. Nguyen, Yong G. Jiang, Betul M. Ogan, Andrew D. Doyle, Duy T. Tran, Jerrold M. Ward, Andrew Zhang, Rafaela Ferrer de Oliveira, Francesca Ferraresso, Jacob R. Bledsoe, Christian J. Kastrup, Matthew J. Flick, R. Grant Rowe, Thomas H. Bugge, Lakmali M. Silva
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