Lindsey George: Understanding the Enhanced Activity of FVIII Aurora
Lindsey George, Assistant Professor of Pediatrics at University of Pennsylvania, Director of Clinical In Vivo Gene Therapy at Children’s Hospital of Philadelphia, shared on LinkedIn about a recent article she and her colleagues co-authored, published in Blood, adding:
”Congratulations Johnathan Morris!
This manuscript describes the underlying mechanism of FVIII Aurora (FVIII-R571S), which has 10–20-fold higher affinity for FIXa over FVIII-WT and FIXa-dependent reduced inactivation by A2-domain dissociation and APC cleavage.”
Title: Factor VIII Aurora: A Naturally Occurring Gain of Function FVIII Variant with Enhanced FIXa Affinity
Authors: Johnathan J. Morris, Robert J Davidson, Connor T. Watson, Lindsey A. George
Stay updated on all scientific advances with Hemostasis Today.
-
Aug 16, 2026, 12:03Fawaz AlOtaibi: Can AI Replace Contrast CTA for Vascular Screening?
-
Aug 16, 2026, 10:31Erhabor Osaro: Critical Issues to Consider During the Clinical Blood Transfusion Process
-
Aug 16, 2026, 10:14Juan Manuel Cisneros Carrasco: The Architects Behind the Blood Donation System
-
Aug 16, 2026, 10:06Honoring the Life and Legacy of Dr. Reed Pyeritz – GADA Canada
-
Aug 16, 2026, 09:51Javier Amador-Castañeda: When a 32 Percent Reduction Tells Only Part of the Story
-
Aug 16, 2026, 09:33Anıl Güneş: The Unseen Threat – How Global Climate Change Impacts Cardiovascular Health
-
Aug 16, 2026, 09:09Robert John Nesbitt: Can We Prevent Stroke Without Increasing Bleeding Risk
-
Aug 16, 2026, 06:19Dennis Wolf: Is ZEUS the End of Anti-Inflammatory Therapy in Atherosclerosis?
-
Aug 16, 2026, 06:05Nicolas Hubacz: A New Target for Stroke Recovery