Lindsey George: Understanding the Enhanced Activity of FVIII Aurora
Lindsey George, Assistant Professor of Pediatrics at University of Pennsylvania, Director of Clinical In Vivo Gene Therapy at Children’s Hospital of Philadelphia, shared on LinkedIn about a recent article she and her colleagues co-authored, published in Blood, adding:
”Congratulations Johnathan Morris!
This manuscript describes the underlying mechanism of FVIII Aurora (FVIII-R571S), which has 10–20-fold higher affinity for FIXa over FVIII-WT and FIXa-dependent reduced inactivation by A2-domain dissociation and APC cleavage.”
Title: Factor VIII Aurora: A Naturally Occurring Gain of Function FVIII Variant with Enhanced FIXa Affinity
Authors: Johnathan J. Morris, Robert J Davidson, Connor T. Watson, Lindsey A. George
Stay updated on all scientific advances with Hemostasis Today.
-
Oct 19, 2026, 19:44Where You Live Should not Determine Whether You Receive Care – World Federation of Hemophilia
-
Oct 19, 2026, 19:42Belen Bianco: Prevention, Early Suspicion and an Interdisciplinary Approach Save Lives
-
Oct 19, 2026, 19:40Christina Chrysohoou: Catheter-Based LAAC vs OAC for Stroke Prevention in Atrial Fibrillation
-
Oct 19, 2026, 19:38Matthew Flick: A Two-Day Research Meeting on Fibrinogen, Hemostasis and Thrombosis
-
Oct 19, 2026, 19:37Hayat Saeed: Excited to Share Our Publication on the FGL1–Hepcidin Axis in Iron Homeostasis and Disease
-
Oct 19, 2026, 19:08IPAW 2026 Comes to a Close, but the Work Continues – PPTA
-
Oct 19, 2026, 17:44Paul Riley: Moderating a Webinar on Anticoagulation Monitoring
-
Oct 19, 2026, 16:36Christopher Pittman: Blood Clot Prevention Cannot End at Hospital Discharge
-
Oct 19, 2026, 16:13Javier M. Floren: When Immune Cells Move With Their Environment