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Michael Makris: 3 PTP Haemophilia A in Japan Have Developed FVIII Inhibitors Following Treatment with Efanesoctocog Alfa
Michael Makris/LinkedIn
Jan 4, 2026, 08:09

Michael Makris: 3 PTP Haemophilia A in Japan Have Developed FVIII Inhibitors Following Treatment with Efanesoctocog Alfa

Michael Makris, Emeritus Professor of Haemostasis and Thrombosis at the University of Sheffield, shared on LinkedIn:

“Three Previously Treated Haemophilia A Patients (PTPs) in Japan have developed FVIII inhibitors following treatment with efanesoctocog alfa (Altuviiio/Altuvoct). One had severe haemophilia, and the other two had moderate and mild disease. Only 38 patients were exposed to efanesoctocog alfa in the centres these 3 patients were reported from.

This is a very much higher rate than expected, and the reasons are unclear.

Was it chance? We will know very soon, as this drug is now used extensively in PTP haemophilia A patients around the world.”

Title: The First Three Japanese Haemophilia A Patients in Whom Factor VIII Inhibitors Were Observed During Prophylactic Treatment With Efanesoctocog Alfa

Authors: Tazuko Tokugawa, Akihiro Sawada, Satoshi Higasa, Mariko Asai, Hideyuki Nakazawa, Azusa Nagao, Tomoko Yamaguchi, Yushi Chikasawa, Masato Bingo, Takeshi Hagiwara, Katsuyuki Fukutake

Michael Makris: 3 PTP Haemophilia A in Japan Have Developed FVIII Inhibitors Following Treatment with Efanesoctocog Alfa

Read more posts from Michael Makris in Hemostasis Today.

Akihiro Sawada Azusa Nagao efanesoctocog alfa FVIII inhibitors haemophilia Health Hemostasis Hemostasis Today Hideyuki Nakazawa Katsuyuki Fukutake Mariko Asai Masato Bingo Medicine Previously Treated Haemophilia A Patients (PTPs) PTP haemophilia A Satoshi Higasa Takeshi Hagiwara Tazuko Tokugawa thrombosis Tomoko Yamaguchi Yushi Chikasawa
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