Mostafa Faisal Mohammed: Avatrombopag in Aplastic Anemia
Mostafa Faisal Mohammed Saleh, Associate professor of Clinical Hematology and HSCT at Assiut University, shared on LinkedIn:
“Our recent publication and 1st in 2026 out in Therapeutic advances in Hematology (IF 3.1)
Avatrombopag in Aplastic Anemia – Review
- Scope: 10 studies (2023–2025), diverse AA settings (frontline, R/R, elderly, liver disease)
- Efficacy: ORR 55–85%; CR up to ~30%
- Onset: Rapid responses, typically within 1–2 months
- Clinical benefit: Multilineage recovery, reduced transfusion needs
- After eltrombopag: Responses seen even in EPAG-refractory/intolerant patients
- Safety: Favorable profile; no meaningful hepatotoxicity or clonal evolution reported
- Key advantage: Suitable for patients with liver dysfunction, no dietary restrictions
Bottom line: Avatrombopag is an effective, well-tolerated TPO-RA with growing role in AA across disease stages”
Title: Efficacy and safety of avatrombopag in aplastic anemia: a comprehensive review of clinical evidence
Authors: Mostafa F. Mohammed Saleh, Abdulrahman Nasiri D, Ahmed Kotb Abdrabou, Alfadil Haroon, Hadeel Samarkandi, Hazza Alzahrani, Mahmoud Aljurf, Ali Alahmari
Read full article here.
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