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Nature Communications Study by Amelia Haj and Colleagues Identifies Factor XII as a Safer Target for Anticoagulation
Amelia Haj/LinkedIn
Oct 7, 2025, 03:40

Nature Communications Study by Amelia Haj and Colleagues Identifies Factor XII as a Safer Target for Anticoagulation

Broad Institute of MIT and Harvard shared on LinkedIn:

”Patients diagnosed with life-threatening blood clots known as venous thromboembolisms (VTEs) are treated with anticoagulants, but these drugs increase their risk of bleeding.

In Nature Communications, Amelia Haj, Patrick Ellinor, Pavan Bendapudi, and collaborators make a genetic case for developing therapies targeting coagulation factor XII, a promising and potentially safer antithrombotic drug target.

They used UK Biobank and All of Us data to show that people who have lost one copy of the F12 gene have lower VTE risk without an increased risk of bleeding.

Their study suggests that inhibiting factor XII would likely be a safe and effective approach for anticoagulation.”

Read the full article in Nature Communications.

Article: Coagulation factor XII haploinsufficiency is protective against venous thromboembolism in a population-scale multidimensional analysis

Authors: Amelia K. Haj, David S. Paul, Sean J. Jurgens, Harish Eswaran, Lu-Chen Weng, Justine Ryu, Alfonso Rodriguez Espada, Sharjeel Chaudhry, Louis M. Feingold, Kristen Burke, Satoshi Koyama, Xin Wang, Joyce Francis, Seung Hoan Choi, Nigel Mackman, Wolfgang Bergmeier, Alex Burgin, Joel T. Rämö, Patrick T. Ellinor, Steven P. Grover , Pavan K. Bendapudi

Nature Communications Study by Amelia Haj and Colleagues Identifies Factor XII as a Safer Target for Anticoagulation

Stay updated on all scientific advances with Hemostasis Today.

Alex Burgin Alfonso Rodriguez Espada All of Us Amelia K. Haj Anticoagulation David S. Paul FXII Harish Eswaran Joel T. Rämö Joyce Francis Justine Ryu Kristen Burke Louis M. Feingold Lu-Chen Weng Nature Communications Nigel Mackman Patrick T. Ellinor Pavan K. Bendapudi Satoshi Koyama Sean J. Jurgens Seung Hoan Choi Sharjeel Chaudhry Steven P. Grover UK Biobank VTE Wolfgang Bergmeier Xin Wang
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