Nicolas Schommer: The Seed and Soil Hypothesis of NET-Mediated Inflammation
Nicolas Schommer, Postdoctoral Researcher at Boston Children’s Hospital, shared a post on LinkedIn about a recent article by Denisa D. Wagner and Lukas Heger, published in Blood, adding:
”Excited to see the latest Perspective from our lab by Denisa Wagner and Lukas Heger, ‘Pathological effects of NETs: seed and soil hypothesis for inflammation spread by primed neutrophils’, now published in print in Blood!
Building on the classical ‘seed and soil’ concept from cancer biology, they propose that circulating primed neutrophils act as the ‘seeds’ of inflammation, while activated endothelium and susceptible organs provide the ‘soil’ for neutrophil extracellular trap (NET)-mediated tissue injury.
The Perspective connects evidence across cardiovascular disease, diabetes, cancer, and other inflammatory conditions, highlighting how NETs may contribute to the propagation of inflammation between organs.
I’m particularly excited to see our previous work on PAD4-dependent NET formation in diabetes-associated cardiac dysfunction discussed within this broader framework.
These concepts also closely connect to the questions we’re currently exploring in the Wagner Lab at Boston Children’s Hospital and Harvard Medical School.”
Title: Pathological effects of NETs: seed and soil hypothesis for inflammation spread by primed neutrophils
Authors: Denisa D. Wagner, Lukas A. Heger
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