Pablo Corral/LinkedIn
Sep 19, 2026, 09:45
Pablo Corral: Is the Classic Model of Hepatic Cholesterol Homeostasis Incomplete?
Pablo Corral, Pharmacology Professor at FASTA University, Past President of Argentine Lipid Society, shared a post on LinkedIn about a recent article by Justine Cole et al., published in Journal of Clinical Lipidology, adding:
“Cholesterol Homeostasis in the Hepatocyte
An extraordinary and truly challenging paper on cholesterol homeostasis
- The hepatocyte is not a fibroblast. The classic SREBP2–LDLR model may not adequately explain hepatic cholesterol homeostasis.
- Not all cholesterol entering the hepatocyte behaves the same. Its intracellular fate may depend on whether it arrives through LDL, chylomicron remnants, or HDL.
- The apoB100 pathway may function largely as a closed cholesterol loop: liver – VLDL – IDL – LDL – liver.
- Provocative concept: LDL may have no significant physiological role in net cholesterol delivery to peripheral tissues—challenging the traditional ‘LDL delivers cholesterol to cells’ paradigm.
- The proposed ‘channel model’ is not yet proven, but it raises a fundamental question: could LDL be better understood as a metabolic end-product of VLDL metabolism rather than a physiologically required cholesterol-delivery system?
A thought-provoking paper that forces us to reconsider some of the most deeply rooted concepts in lipoprotein physiology.
Congrats Rafael Zubiran and co-authors.”
Title: Cholesterol Homeostasis in the Hepatocyte
Authors: Justine Cole, Iana Pencinaa, Robert Kiss, Rafael Zubiranb, Allan D. Sniderman
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