Patrick Badertscher: PVI With vs Without Posterior Wall Isolation in Persistent AF
Patrick Badertscher, Privat-Docent (PD) in Cardiology at University of Basel, shared a post on LinkedIn about a recent article by Laurent Roten et al., published in JAMA, adding:
“Exited to share PIFPAF-PFA.
Today, the PIFPAF-PFA randomized trial was presented as a Late-Breaking Clinical Trial at ESC Congress 2026 and simultaneously published in JAMA
We asked: In persistent AF, should posterior wall isolation be added to PVI when using pulsed-field ablation?
PVI and PWI did not significantly improve freedom from atrial tachyarrhythmia compared with PVI alone.
However, continuous rhythm monitoring showed lower arrhythmia burden and fewer longer-lasting episodes with PWI.
Our findings challenge us to look beyond the traditional greater-than-30-second recurrence endpoint when assessing AF ablation outcomes.
Proud to have been part of this investigator-initiated trial and grateful to all patients, investigators, study teams, and participating centers who made it possible.”
Title: Pulmonary Vein Isolation Using Pulsed Field Ablation With vs Without Posterior Wall Isolation in Patients With Symptomatic Persistent Atrial Fibrillation
Authors: Laurent Roten, Jens Maurhofer, Philipp Krisai, Alexander Breitenstein, Pascal Koepfli, Ardan M. Saguner, Florian Franzeck, Patrizio Pascale, Thomas Kueffer, Sven Knecht, Corinne Jufer, Valon Spahiu, Nicolas Schaerli, Claudia Herrera Siklody, Gregor Thalmann, Nikola Kozhuharov, Boldizsar Kovacs, Felix Mahfoud, Dik Heg, Tiago V. Pereira, Helge Servatius, Hildegard Tanner, Michael Kühne, Christian Sticherling, Tobias Reichlin, Peter Jüni, Patrick Badertscher
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