General Anesthesia May Lead to Better Outcomes in Stroke Thrombectomy?
Fawaz Al-Mufti, Associate Dean for Research and Innovation at Westchester Medical Center, shared a post on LinkedIn:
“SEGA says… GAME OVER for the GA vs Sedation debate.
May be?
Fresh in JAMA Neurology, the SEGA Randomized Trial put general anesthesia head-to-head with moderate sedation for mechanical thrombectomy in large vessel occlusion stroke, giving us some randomized clarity on an age-old debate in stroke thrombectomy: GA or sedation?
260 patients, 10 U.S. stroke centers, randomized head-to-head.
Randomized 1:1 GA vs sedation
At 90 days: GA favored with OR 1.22 (CrI 0.79–1.87), 81% probability of superiority
Reperfusion: higher with GA (69% probability)
Symptomatic ICH: 0.8% GA vs 2.4% sedation
Translation: GA pulled ahead with better 90-day outcomes and higher reperfusion rates.
Safety? Pretty comparable.
Bottomline: putting patients to sleep may actually wake up better outcomes.
Congrats to the SEGA investigators and P. Roc Chen, MD, FAANS, FACS for turning a long-running debate into data.”
Title: Sedation vs General Anesthesia for Endovascular Therapy in Acute Ischemic Stroke
Authors: Peng Roc Chen, Carlos A. Artime, Sunil A. Sheth, Claudia Pedroza, Santiago Ortega-Gutierrez, Stacey Wolfe, Clark Sitton, Peter Kan, Omar Tanweer, Alex Chebl, Clemens M. Schirmer, Jay T. Morrow, Yazan J. Alderazi, Bradley Bohnstedt, Kadir Erkmen, Edgar A. Samaniego, Elena Garrido, Sean I. Savitz, Allison Engstrom, Eddie Aguilar, Tien Nguyen, Andrew D. Barreto
Read the full article here.
Stay updated on all scientific advances in the field of bleeding disorders with Hemostasis Today.
-
May 23, 2026, 03:55WFH Initiative Brings Hope to the Hemophilia Community in India
-
May 23, 2026, 03:47Satyam Arora: Welcoming the New ISBT Board for the 2026 Term
-
May 23, 2026, 03:33Brig Tathagata Chatterjee: Connecting With World Leaders in Hematology at ISH Congress
-
May 23, 2026, 03:18Mathangi Kumar: Dental Management Strategies for Congenital Hemophilia
-
May 23, 2026, 03:02Maitri Vaishnav: Anatomical Variability and Surgical Relevance of Corona Mortis
-
May 23, 2026, 02:26Muhammad Hashim: When the Blood Smear Told a Different Story Behind a ‘Critical’ Platelet Count
-
May 23, 2026, 02:20Augustina Isioma Ikusemoro: Understanding One of the Most Common and Preventable Transfusion Reactions
-
May 23, 2026, 02:15What’s Your Advice for the Newly Diagnosed? – ITP Support Association
-
May 23, 2026, 02:08Rob Maloney: When You Stop Building Only a Career and Start Building a Life of Significance