General Anesthesia May Lead to Better Outcomes in Stroke Thrombectomy?
Fawaz Al-Mufti, Associate Dean for Research and Innovation at Westchester Medical Center, shared a post on LinkedIn:
“SEGA says… GAME OVER for the GA vs Sedation debate.
May be?
Fresh in JAMA Neurology, the SEGA Randomized Trial put general anesthesia head-to-head with moderate sedation for mechanical thrombectomy in large vessel occlusion stroke, giving us some randomized clarity on an age-old debate in stroke thrombectomy: GA or sedation?
260 patients, 10 U.S. stroke centers, randomized head-to-head.
Randomized 1:1 GA vs sedation
At 90 days: GA favored with OR 1.22 (CrI 0.79–1.87), 81% probability of superiority
Reperfusion: higher with GA (69% probability)
Symptomatic ICH: 0.8% GA vs 2.4% sedation
Translation: GA pulled ahead with better 90-day outcomes and higher reperfusion rates.
Safety? Pretty comparable.
Bottomline: putting patients to sleep may actually wake up better outcomes.
Congrats to the SEGA investigators and P. Roc Chen, MD, FAANS, FACS for turning a long-running debate into data.”
Title: Sedation vs General Anesthesia for Endovascular Therapy in Acute Ischemic Stroke
Authors: Peng Roc Chen, Carlos A. Artime, Sunil A. Sheth, Claudia Pedroza, Santiago Ortega-Gutierrez, Stacey Wolfe, Clark Sitton, Peter Kan, Omar Tanweer, Alex Chebl, Clemens M. Schirmer, Jay T. Morrow, Yazan J. Alderazi, Bradley Bohnstedt, Kadir Erkmen, Edgar A. Samaniego, Elena Garrido, Sean I. Savitz, Allison Engstrom, Eddie Aguilar, Tien Nguyen, Andrew D. Barreto
Read the full article here.
Stay updated on all scientific advances in the field of bleeding disorders with Hemostasis Today.
-
Jan 7, 2026, 08:50Fahad Khaliq on When is Ticagrelor Preferred Over Other Antiplatelets
-
Jan 7, 2026, 06:41Zain Khalpey on AI Driven Risk Prediction for Optimization of Anticoagulation in LVAD
-
Jan 7, 2026, 05:47Michael Makris: The Wakley Prize Essay Published in Today’s Lancet is an Excellent Read
-
Jan 7, 2026, 05:36Pierre F Sabouret Shares A Study on the Risk of Cardiovascular Death in SIDs
-
Jan 7, 2026, 05:15Glaivy Batsuli Reflects on ASH25
-
Jan 7, 2026, 05:04Heghine Khachatryan on VWD: A Landmark in the History of Hematology
-
Jan 6, 2026, 13:39JAMA Neurology: No Added Benefit of Dual Therapy After Ischemic Stroke in Case of AFib
-
Jan 6, 2026, 10:10This is Fantastic: Shirley D’Sa on Transfusion-Free Christmas Milestone for 𝛃-Thalassaemia Patient at UCLH
-
Jan 6, 2026, 09:53Hamideh Yadegari: Coagulation–Inflammation Crosstalk: Mechanisms, Pathways, and Clinical Implications