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Zeyad Kholeif: New Evidence Challenges Routine Triple Antithrombotic Therapy After Anterior STEMI
Zeyad Kholeif/LinkedIn
Jul 12, 2026, 23:19

Zeyad Kholeif: New Evidence Challenges Routine Triple Antithrombotic Therapy After Anterior STEMI

Zeyad Kholeif, Resident Doctor at Baptist Hospitals of Southeast Texas Internal Medicine Residency, Research Scholar at Mayo Clinic, shared a post on LinkedIn about a recent article he and his colleges co-authored, published in Clinical and Applied Thrombosis/Hemostasis, adding:

”New Publication!

Our updated meta-analysis is now published in Clinical and Applied Thrombosis/Hemostasis.

7 studies | 2,273 patients

Compared with DAPT alone, prophylactic triple antithrombotic therapy after anterior STEMI:

  • Did not significantly reduce LV thrombus
  • No reduction in mortality or thromboembolic events
  • Increased major bleeding

Take-home message: Routine prophylactic triple therapy may not be justified—careful patient selection remains essential.”

Title: Triple Antithrombotic Therapy vs Dual Antiplatelet for Prevention of Left Ventricular Thrombus After Anterior Myocardial Infarction: An Updated Meta-Analysis

Authors: Mustafa Abomohsen, Ibrahim Elkhayat, Ahmed Elmorsy Mohamed, Abdul Hakim Almakadma, Zeyad Kholeif, Ahmed Farid Gadelmawla, Ameer Awashra, Muhammed A. Youssef, Osamah AlQassab, Mohamed Ghannam, Vikas Patel, Azad Mojahedi, Iyad Idries, Meena Farid, Moshe Gunsburg, Hal L. Chadow

Zeyad Kholeif: New Evidence Challenges Routine Triple Antithrombotic Therapy After Anterior STEMI

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Clinical and Applied Thrombosis/Hemostasis Health Hematology Hemostasis Hemostasis News Hemostasis Today LV thrombus Medicine STEMI thromboembolic stroke thrombosis Zeyad Kholeif
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