Adela Castro/X
Nov 14, 2026, 14:24
Adela Castro: Distinguishing Antiphospholipid Antibodies From APS in Pregnancy
Adela Castro, Assistant Professor of Rheumatology at University of Tennessee Health Science Center (Memphis), shared a post on X:
“APL versus APS in Pregnancy: Same Antibody, Different Plan
- APL but no APS: no anticoagulation; low-dose aspirin (LDASA) may reduce preeclampsia risk
- Obstetric APS: LDASA plus prophylactic LMWH, continued through 6 weeks postpartum
- Thrombotic APS: LDASA plus treatment-dose LMWH; consider HCQ
About 20 percent of pregnancies still fail despite LMWH, because placental injury is also inflammatory and complement-mediated, so consider HCQ.
IMPACT study: adding certolizumab to standard APS care appeared to increase live birth rates and reduce adverse pregnancy outcomes.”
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