Laurent Bertoletti on Impact of Anticoagulants on Survival in Pulmonary Arterial Hypertension
Laurent Bertoletti, University Professor and Hospital Practitioner at Jean Monnet University, Saint-Etienne, shared on LinkedIn:
”Do anticoagulants really improve survival in pulmonary arterial hypertension (PAH)?
Our study shows that routine anticoagulation does not confer an overall survival benefit: analysis of 1,597 patients from the French PAH registry found no significant reduction in mortality (HR 0.997; 95% CI 0.84–1.18).
These results were consistents across PAH subgroups, and confirmed by an updated meta-analysis.
The discussion is open!
Why this study?
The use of anticoagulants in PAH remains controversial, with prior evidence limited to observational data and often contradictory.
- We examined the French PAH Registry, drawing on robust methodology and biostatistics expertise . Céline Chapelle with the help of Silvy Laporte and Edouard Ollier.
- We analyzed 1,597 incident patients diagnosed with PAH between 2009 and 2020, each with at least 3 years of follow-up. After propensity‑score matching, no survival benefit was found in any PAH subtype.
- We then performed a meta‑analysis of contemporary national registry studies. The results confirm no significant reduction in mortality with anticoagulants (HR 0.98; 95% CI 0.78–1.23), regardless of PAH subgroup.
Overall, anticoagulation does not provide a measurable survival benefit. In the absence of randomized trials and given the risk of bleeding, this strategy should be reserved for carefully selected patients.
These results do not apply to patients with validated indication for anticoagulant therapy, as AF or VTE
Jean Escal, David Montani, Athénaïs Boucly, Laurent Savale, Xavier Jais, Xavier Delavenne and the others co-authors, and all the PULMOTENSION network from RespiFil
Thanks to all the patients and research teams for their contributions, and to the JACC Journals editorial team”
Read the full article in JACC Journals.
Article: Association Between Anticoagulant Therapy and Survival in Pulmonary Arterial Hypertension: A Registry Report and Updated Meta-Analysis
Authors: Laurent Bertoletti,Jean Escal, Athénaïs Boucly, Ségolène Turquier, Mitja Jevnikar, Nicolas Lamblin, Souad Bezzeghoud, Celine Chapelle, Xavier Delavenne, Laurent Savale, Marc Humbert, David Montani, Olivier Sitbon, and Xavier Jais
Stay updated on all scientific advances with Hemostasis Today.
-
Sep 29, 2025, 12:54Microfluidic Technology Uncovers Ongoing TTP Disease Activity
-
Sep 29, 2025, 12:43Advancing Thrombosis Research: MRI-Based Methodology for Studying Thrombus Resolution
-
Sep 29, 2025, 05:58Samwel Mikaye on Understanding, Diagnosing, and Managing Deep Venous Thrombosis (DVT)
-
Sep 28, 2025, 14:08Mary Cushman: Dr Warkentin Is a Giant in Hematology
-
Sep 28, 2025, 13:31Michael Makris Highlights Vaccine Misinformation and Its Risks
-
Sep 29, 2025, 12:33Allison Wheeler: Some Days I Love Science a Little Bit More
-
Sep 29, 2025, 06:23Yudi Hardianto and Colleagues Give a Review on Stroke Rehabilitation in LMICs
-
Sep 29, 2025, 04:42Wolfgang Miesbach on the Bi8 Study: A Novel FVIII-Mimetic Antibody Gene Therapy for Haemophilia A
-
Sep 29, 2025, 04:16Salvador Payán Pernía on Equity Challenges in Access to Gene Therapy for Hemoglobinopathies
-
Sep 29, 2025, 04:02Nicolas Gendron: A Very Nice Demonstration by The Authors - Coffee is Associated with Reduced Risk of VTE
-
Sep 29, 2025, 05:06Sue Bacon on the Importance of Addressing Hospital-Acquired DVT and PE
-
Sep 24, 2025, 11:06Wolfgang Miesbach Reports Promising Results for New Subcutaneous von Willebrand Disease Therapy VGA039
-
Sep 23, 2025, 06:40Richard Buka: CSL Behring Have Announced a Collaboration with Dutch Biotech, VarmX
-
Sep 22, 2025, 07:10Aspirin Beyond the Heart․ Targeting PI3K-Altered Colorectal Cancer
-
Sep 22, 2025, 06:04ClearPlasma: A New Filter Technology to Enhance Clot Stability in Donated Plasma
-
Sep 29, 2025, 07:02Kambua Manundu: We Walked to Protest the Countless Lives of Women We Have Lost to Post Partum Hemorrhage
-
Sep 29, 2025, 06:41Ouma Oluga Unveiled Plans to Make Sickle Cell Screening Mandatory in Kenya at 80th UN General Assembly
-
Sep 29, 2025, 04:51Nathan Connell on Breakthrough Gene Therapy Advancing Care for People with Hemophilia
-
Sep 29, 2025, 04:28Emmeran Hauser: Fantastic to See First Results of Our Work in Europe
-
Sep 28, 2025, 10:33Côme Bommier: Burnout Is Common Among Hematology Professionals