Abdul Mannan on CVT risk with CHC: It is Not One-Size-Fits-All!
Abdul Mannan, Consultant Haematologist at Betsi Cadwaladr University Health Board, shared on LinkedIn:
”CVT risk with CHC is not one-size-fits-all.
The type of progestin matters enormously (fourth-generation worst), and the multiplication of risk factors (family history, thrombophilia, obesity) creates scenarios with 200+ fold increased risk.
Most important clinical change:
- Take family history more seriously – it predicts risk independently of thrombophilia testing.
- And if you’re prescribing CHC, think twice about fourth-generation progestins.
The absolute risk remains low for most women, but for that high-risk subset (family history + thrombophilia), the numbers are sobering enough to have serious conversations about alternative contraception.”
Read the full article in JTH.
Article: The risk of cerebral vein thrombosis associated with different types of combined hormonal contraceptives: a case-control study
Authors: Maria Abbattista, Addolorata Truma, Ida Martinelli, Francesca Gianniello, Serena M. Passamonti, Marco Capecchi, Andrea Artoni, Flora Peyvandi, Paolo Bucciarelli
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