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Casper Nielsen: Cold Fluid Administration Had Minimal Impact on Overall Hemostasis
Casper Nielsen/LinkedIn
Oct 4, 2025, 12:29

Casper Nielsen: Cold Fluid Administration Had Minimal Impact on Overall Hemostasis

Casper Nielsen, Physician at Fælles Akutmodtagelse FAM (OUH), shared a post on  LinkedIn:

”Publication Announcement

We are proud to present the article: “10° vs. 22° Celsius Cold Fluid Bolus Does Not Affect Hemostasis in Healthy Adults – A Randomized Crossover Trial”

The article is available at the following link.

In this study, we investigated how a 1 liter bolus of cold Ringer’s lactate affects hemostasis. Our hypothesis was to examine the effects of administering 1 liter of Ringer’s lactate at 10 °C , versus 22 °C on hemostasis.

Highlights:

  • Administration of cold intravenous fluids can provide positive hemodynamic effects.
  • A bolus of cold Ringer’s lactate slightly prolonged clotting time by 2.6 seconds.
  • Cold fluid administration had minimal impact on overall hemostasis.
  • 1 liter of 10 °C Ringer’s lactate was deemed safe in healthy adults.

Many thanks to:
Ane Johanne Davidsen Dahlberg, Mikkel Brabrand, Lasse Paludan Bentsen, Camilla Schade Skov, Line Emilie Laugesen, Mette Rahbek Kristensen, Mette Løkke, Christian Nielsen, Pernille Just Vinholt, Peter Biesenbach and the Emergency Medicine Research Unit at OUH.”

Title: 10° compared to 22° celsius cold fluid bolus does not affect hemostasis in healthy adults – A randomized crossover trial

Authors: Casper Nielsen, Ane Johanne Davidsen Dahlberg, Mikkel Brabrand, Lasse Paludan Bentsen, Camilla Schade Skov, Line Emilie Lilholm Laugesen, Mette Rahbek Kristensen, Mette Løkke, Christian Nielsen, Pernille Just Vinholt, Peter Biesenbach

Casper Nielsen

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Ane Johanne Davidsen Dahlberg Camilla Schade Skov Casper Nielsen Christian Nielsen Cold Fluid Health Hematology Hemodynamic Effects Hemostasis Hemostasis Today Lasse Paludan Bentsen Line Emilie Lilholm Laugesen Medicine Mette Løkke Mette Rahbek Kristensen Mikkel Brabrand Pernille Just Vinholt Peter Biesenbach Ringer's Lactate
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