William Wallace: Magnesium – Role in Blood Pressure Regulation
William Wallace, Director of Product Development and Scientific Affairs at ProHealth Longevity, shared on X:
“Magnesium plays an important role in blood pressure regulation, as demonstrated by its influence on endothelial function, calcium efflux, and oxidative stress. Magnesium deficiency can contribute to endothelial dysfunction, increased oxidative stress, and vascular remodeling, all of which exacerbate hypertension and cardiovascular disease risk. Supplementation with magnesium has been shown to induce vasodilation, decrease vascular tone, and improve blood pressure outcomes. A recent umbrella meta-analyses (PMID: 39280209) found that magnesium doses ≥400 mg/day, administered for a duration of ≥12 weeks, can significantly reduce both systolic and diastolic blood pressure (SBP: -6.38 mmHg; DBP: -3.71 mmHg) – mostly in people with previous metabolic disorder (and also likely to have inadequate magnesium status before supplementing).
Mechanistically, magnesium influences nitric oxide production, prostaglandin synthesis, and calcium channel function, which collectively promote vasodilation and attenuate blood pressure increases.
In practice, ensuring sufficient magnesium intake may offer long-term cardiovascular benefits, especially when integrated into a broader strategy (as magnesium alone is not strong enough to function as a “monotherapy” for treating hypertension) targeting endothelial health, oxidative stress reduction, and vascular integrity.”
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