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Anand Padmanabhan Presents a Case Series of HIT Patients with Negative Results in HIT ELISAs
Anand Padmanabhan/LinkedIn
Nov 25, 2025, 09:07

Anand Padmanabhan Presents a Case Series of HIT Patients with Negative Results in HIT ELISAs

Anand Padmanabhan, Professor and Consultant at Mayo Clinic, shared a post on LinkedIn:

“Excited to present a case series of HIT patients with NEGATIVE results in HIT ELISAs that use targets such as polyvinylsulfonate/PF4 and heparin/PF4, which are the commonest antigens used in HIT diagnostic kits. These antibodies activate platelets, and re-exposure of the patients to heparin based on these negative results ended in platelet counts dropping again, confirming HIT. This study emphasizes the importance of functional testing to make an accurate diagnosis especially in patients with a complex clinical course. I want to acknowledge colleagues from various institutions who contributed cases to this study. Have you seen such patients in your practice? Could this phenomenon be under-recognized?”

Title: Pathogenic PF4/Polyvinylsulfonate ELISA-negative Antibodies in HIT

Authors: Adam J. Kanack, Noah P. Splinter, Emily E. Mauch, Leben Tefera, Morayma Reyes Gil, Sakshi Jasra, Andrew Goodwin, Kristi J Smock, Hadiyah Ahmad, Aneel Ashrani, Nathaniel L. Robinson, Ana I. Casanegra, Curtis G. Jones, Shannon M. Pechauer, Erin Yttre, Richard H. Aster, Mindy C. Kohlhagen, Rachel R. Leger, David L. Murray, Lu Zhou, Demin Wang, Renren Wen, Dong Chen, Rajiv K. Pruthi, Anand Padmanabhan

Anand Padmanabhan Presents a Case Series of HIT Patients with Negative Results in HIT ELISAs

Read full study here.

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Adam J. Kanack Ana I. Casanegra Anand Padmanabhan Andrew Goodwin Aneel Ashrani Curtis G. Jones David L. Murray Demin Wang Dong Chen Emily E. Mauch Erin Yttre Hadiyah Ahmad Health Hematology Hemostasis Hemostasis Today heparin/PF4 HIT HIT ELISAs Kristi J Smock Leben Tefera Lu Zhou Medicine Mindy C. Kohlhagen Morayma Reyes Gil Nathaniel L. Robinson Noah P. Splinter platelets polyvinylsulfonate/PF4 Rachel R. Leger Rajiv K. Pruthi Renren Wen Richard H. Aster Sakshi Jasra Shannon M. Pechauer
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