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When TACO Runs Hot: Rethinking Fever in Transfusion-Associated Circulatory Overload
Caitlin R./LinkedIn
Nov 25, 2025, 09:23

When TACO Runs Hot: Rethinking Fever in Transfusion-Associated Circulatory Overload

Caitlin Raymond, Assistant Professor of Pathology and Transfusion Medicine at the University of Wisconsin-Madison, shared on LinkedIn:

”We’re taught that transfusion-associated circulatory overload (TACO) is purely hemodynamic – too much volume, too fast. But what if that’s only half the story?

Emerging data suggest that up to 40% of TACO cases involve fever, and not as a coincidence. These “hot-TACO” presentations hint at a proinflammatory component, challenging the traditional binary between “volume overload” and “immune reaction.”

In my latest post for Blood, Bytes, and Beyond, I explore:
– The evidence linking fever and inflammation to TACO
– How this blurs the line between TACO, TRALI, and sepsis

If you’ve ever struggled to distinguish these reactions at the bedside, or wondered why some TACO cases seem too intense for the volume given, this one’s for you.

Read the full piece here.”

Title: When TACO Runs Hot: Rethinking Fever in Transfusion-Associated Circulatory Overload

Author: Caitlin Raymond

Transfusion

 

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