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New ASH25 Insights on Bleeding Risk in Cancer-Associated VTE
Marc Carrier/X
Dec 8, 2025, 06:23

New ASH25 Insights on Bleeding Risk in Cancer-Associated VTE

Marc Carrier, Professor at Ottawa Hospital Research Institute, shared on LinkedIn:

”New Insights on Bleeding Risk During Extended Anticoagulation in Cancer-Associated VTE

Presented at ASH25 and published in Lancet Haematology, this post-hoc analysis of the API-CAT trial, led by Prof. Isabelle Mahé, identifies key predictors of clinically relevant bleeding during extended apixaban therapy in patients with active cancer.

Key Predictors of Higher Bleeding Risk
• Anemia and/or thrombocytopenia (HR 1.93)
• Age ≥75 years (HR 1.51)
• Index pulmonary embolism (HR 1.47)
• Male sex (HR 1.38)
These predictors were consistent across cancer types and also aligned with predictors of major bleeding. See manuscript here.”

Title: Predictors of clinically relevant bleeding during extended anticoagulation for cancer-associated venous thromboembolism (API-CAT): a post-hoc analysis of a randomised, non-inferiority trial

Authors: Prof Isabelle Mahé, Céline Chapelle, Philippe Girard, Marc Carrier, Luis Jara Palomares, Prof Charles-Marc Samama, Hélène Helfer, Prof Grigoris Gerotziafas, Prof Silvy Laporte, Prof Eric Vicaut, Prof Patrick Mismetti

Bleeding Risk

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American Society of Hematology Anticoagulation API-CAT Trial ASH ASH2025 ASH25 Bleeding Risk Cancer Care Cancer-associated VTE Celine Chapelle Clinical Research extended anticoagulation Health Hélène Helfer Hematology Hemostasis Hemostasis Today Lancet Haematology LinkedIn Science Luis Jara-Palomares Marc Carrier Medicine Ottawa Hospital Research Institute Philippe Girard Prof Charles-Marc Samama Prof Eric Vicaut Prof Grigoris Gerotziafas Prof Isabelle Mahé Prof Patrick Mismetti Prof Silvy Laporte Risk Stratification thrombosis venous thromboembolism VTE
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