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James Morrissey Shares the Explanation of A Literally 30 Years Worth of TF Biochemistry
James Morrissey/University of Michigan Medical School
Dec 13, 2025, 17:20

James Morrissey Shares the Explanation of A Literally 30 Years Worth of TF Biochemistry

James Morrissey, Professor at University of Michigan Medical School, shared on LinkedIn:

”Delighted that our cryo-EM structure of the membrane-bound enzyme that triggers blood clotting — the tissue factor (TF)/factor VIIa (FVIIa) complex — was featured on the cover of the 4 December 2025 issue of Blood!

It reveals a previously unknown, membrane-dependent allosteric mechanism that explains literally 30 years’ worth of TF biochemistry that lacked a unified explanation.

Plus, it provides a mechanistic explanation for the puzzling phenomenon of TF encryption/decryption on cell surfaces.

Josepha Sezdro in my lab worked closely with Amanda Photenhauer in Melanie Ohi‘s lab (plus a host of other talented collaborators) to solve this structure.”

Read the full article here.

Article: Cryo-EM structure of the tissue factor/factor VIIa complex with a factor X mimetic reveals a novel allosteric mechanism

Authors: Josepha C. Sedzro, Amanda L. Photenhauer, Fabienne Birkle, Katarina Meze, Alex Mortenson, Cade Duckworth, Po-Chao Wen, Sarah Kearns, Michael A. Cianfrocco, Emad Tajkhorshid, Melanie D. Ohi, James H. Morrissey

James Morrissey Shares the Explanation of A Literally 30 Years Worth of TF Biochemistry

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Alex Mortenson Amanda L. Photenhauer ASH Blood Cade Duckworth Cryo-EM Emad Tajkhorshid Fabienne Birkle James H. Morrissey James Morrissey Josepha C Sedzro Katarina Meze Melanie D. Ohi Michael A. Cianfrocco Po-Chao Wen Sarah Kearns TF
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