Phagocytosed Clues: A Cryoglobulinemia Case Unfolds at the Microscopic Level-by the American Journal of Hematology
American Journal of Hematology shared a post on X:
“46-year-old woman with fever, abdominal pain
Labs: anemia, +SPEP
Cryoglobulins on blood smear phagocytosed by neutrophils and precipitated in serum
Dx: Cryoglobulinemia”
A 46-year-old woman presented with fever and abdominal pain. Laboratory workup revealed anemia and a positive serum protein electrophoresis (SPEP). Strikingly, cryoglobulins were identified on peripheral blood smear—actively phagocytosed by neutrophils and visibly precipitated in serum, confirming the diagnosis of cryoglobulinemia.
This case underscores the diagnostic power of morphologic hematology and highlights the intersection of immune dysregulation and hematologic pathology. Clinicians should maintain high suspicion for cryoglobulinemia in patients with unexplained systemic symptoms and abnormal SPEP, especially when direct smear findings are available.
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