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Nathan Connell on Real-World Evidence: A Safe Switch to New rFVIIa Avoided Over $550K in Costs
Nathan Connell/LinkedIn
Jan 5, 2026, 05:54

Nathan Connell on Real-World Evidence: A Safe Switch to New rFVIIa Avoided Over $550K in Costs

Nathan Connell, Clinical Chief of Hematology at Brigham and Women’s Faulkner Hospital, shared on LinkedIn:

“New Research: Real-World Evidence on Recombinant Factor VIIa Substitution

I’m excited to share our team’s latest publication in Clinical and Applied Thrombosis/Hemostasis. We conducted a retrospective evaluation of our conversion from eptacog alfa (NovoSeven) to eptacog beta (Sevenfact) to assess both clinical safety and financial impact at Brigham and Women’s Hospital.

Key Findings:

  •  Safety: The transition to eptacog beta showed no adverse thrombotic events across the patient cohort.
  •  Efficacy: Effective management was maintained for indications including hemophilia bleeding and peri-procedural management.
  •  Impact: The medication use evaluation identified an estimated cost avoidance of $554,400 over 12 months.

This study supports the viability of therapeutic interchange for rFVIIa products, offering a pathway for other institutions to maintain high-quality care while optimizing costs.

Read the full open-access article here.”

Title: Real World Experience with use of Coagulation Factor VIIa at an Academic Medical Center

Authors: Alyssa R. George, Katelyn W. Sylvester, Dareen M. Kanaan, Prabashni Reddy, John R. Fanikos, Jean M. Connors, Nathan T. Connell

Nathan Connell on Real-World Evidence: A Safe Switch to New rFVIIa Avoided Over $550K in Costs

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Alyssa R. George Brigham and Women's Hospital Dareen M. Kanaan eptacog alfa factor VIIa Health Hemostasis Hemostasis Today Jean M. Connors John R. Fanikos Katelyn W. Sylvester Medicine Nathan T. Connell Prabashni Reddy RfviiA thrombosis
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