Nathan Connell on Real-World Evidence: A Safe Switch to New rFVIIa Avoided Over $550K in Costs
Nathan Connell, Clinical Chief of Hematology at Brigham and Women’s Faulkner Hospital, shared on LinkedIn:
“New Research: Real-World Evidence on Recombinant Factor VIIa Substitution
I’m excited to share our team’s latest publication in Clinical and Applied Thrombosis/Hemostasis. We conducted a retrospective evaluation of our conversion from eptacog alfa (NovoSeven) to eptacog beta (Sevenfact) to assess both clinical safety and financial impact at Brigham and Women’s Hospital.
Key Findings:
- Safety: The transition to eptacog beta showed no adverse thrombotic events across the patient cohort.
- Efficacy: Effective management was maintained for indications including hemophilia bleeding and peri-procedural management.
- Impact: The medication use evaluation identified an estimated cost avoidance of $554,400 over 12 months.
This study supports the viability of therapeutic interchange for rFVIIa products, offering a pathway for other institutions to maintain high-quality care while optimizing costs.
Read the full open-access article here.”
Title: Real World Experience with use of Coagulation Factor VIIa at an Academic Medical Center
Authors: Alyssa R. George, Katelyn W. Sylvester, Dareen M. Kanaan, Prabashni Reddy, John R. Fanikos, Jean M. Connors, Nathan T. Connell
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