Nathan Connell on Real-World Evidence: A Safe Switch to New rFVIIa Avoided Over $550K in Costs
Nathan Connell, Clinical Chief of Hematology at Brigham and Women’s Faulkner Hospital, shared on LinkedIn:
“New Research: Real-World Evidence on Recombinant Factor VIIa Substitution
I’m excited to share our team’s latest publication in Clinical and Applied Thrombosis/Hemostasis. We conducted a retrospective evaluation of our conversion from eptacog alfa (NovoSeven) to eptacog beta (Sevenfact) to assess both clinical safety and financial impact at Brigham and Women’s Hospital.
Key Findings:
- Safety: The transition to eptacog beta showed no adverse thrombotic events across the patient cohort.
- Efficacy: Effective management was maintained for indications including hemophilia bleeding and peri-procedural management.
- Impact: The medication use evaluation identified an estimated cost avoidance of $554,400 over 12 months.
This study supports the viability of therapeutic interchange for rFVIIa products, offering a pathway for other institutions to maintain high-quality care while optimizing costs.
Read the full open-access article here.”
Title: Real World Experience with use of Coagulation Factor VIIa at an Academic Medical Center
Authors: Alyssa R. George, Katelyn W. Sylvester, Dareen M. Kanaan, Prabashni Reddy, John R. Fanikos, Jean M. Connors, Nathan T. Connell
Explore more posts for deeper insights into hemostasis with Hemostasis Today.
-
Apr 8, 2026, 15:21Nathan Connell: Persistent Gaps in Hemophilia A Care Despite Prophylaxis
-
Apr 8, 2026, 15:16Avril Mansfield: Why Aren’t More Stroke Patients Meeting Aerobic Exercise Guidelines?
-
Apr 8, 2026, 15:06Sarah Richardson: We Need Experts, We Need Programs and We Need Accountability in Blood Disorders Community
-
Apr 8, 2026, 15:02Heghine Khachatryan: When Bleeding Appears Without a History — Think Acquired
-
Apr 8, 2026, 14:58Nominate a Bleeding Disorders Community Hero Making a Difference – NBDF
-
Apr 8, 2026, 14:56Joffrey Feriel: Comprehensive Review of Laboratory Assays for von Willebrand Factor and Associated Disorders
-
Apr 8, 2026, 14:54Husnain Ahmad: How Aortic Stenosis Can Lead to Gastrointestinal Bleeding in Heyde Syndrome
-
Apr 8, 2026, 14:51Steven Murphy: How Much Benefit Do Statins Really Provide for Cardiovascular Prevention
-
Apr 8, 2026, 14:42Joshua Muia: The Value of Collaboration and The Importance of Exchanging Ideas Across Institutions