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Erwin Loh: Immunotherapy Reduces Plaque in Arteries of Mice
Professor Erwin Loh/LinkedIn
Feb 1, 2026, 12:16

Erwin Loh: Immunotherapy Reduces Plaque in Arteries of Mice

Erwin Loh,  President of Royal Australasian College of Medical Administrators, shared a post on LinkedIn about a recent article by Junedh M. Amrute et al, published in Science:

“Immunotherapy reduces plaque in arteries of mice

Scientists have designed an immunotherapy that reduces plaque in the arteries of mice, presenting a possible new treatment strategy against heart disease.

The antibody-based therapy could complement traditional methods of managing coronary artery disease that focus on lowering cholesterol through diet or medications such as statins.

Such an immunotherapy could especially help patients who already have plaque in their coronary arteries and remain at high risk of heart attack even if they’re able to achieve low cholesterol levels in the blood.

The study is published Jan. 29 in the journal Science.”

Title: Targeting modulated vascular smooth muscle cells in atherosclerosis via FAP-directed immunotherapy

Authors: Junedh M. Amrute, In-Hyuk Jung, Tracy Yamawaki, Wen-Ling Lin, Andrea Bredemeyer, Johanna Diekmann, Sikander Hayat, Xianglong Zhang, Devin L. Wakefield, Xin Luo, Sidrah Maryam, Gyu Seong Heo, Steven Yang, Chang Jie Mick Lee, Chen Wang, Caroline Chou, Christoph Kuppe, Kevin D. Cook, Atilla Kovacs, Vishnu Chintalgattu, Danielle Pruitt, Jose Barreda, Nathan O. Stitziel, Paul Cheng, Yongjian Liu, Rafael Kramann, Daniel Kreisel, Roger S-Y Foo, Ingrid C. Rulifson, Scott Martin, David Grunert, Melissa Thomas, Jixin Cui, Thomas Quertermous, Frank M. Bengel, Simon Jackson, Chi-Ming Li, Brandon Ason, Kory J. Lavine

Read the Full Article on Science

Erwin Loh: Immunotherapy Reduces Plaque in Arteries of Mice

More posts featuring Erwin Loh.

 

Andrea Bredemeyer Atilla Kovacs Brandon Ason Caroline Chou Chang Jie Mick Lee Chen Wang Chi-Ming Li Christoph Kuppe Daniel Kreisel Danielle Pruitt David Grunert Devin L. Wakefield Erwin Loh Frank M. Bengel Gyu Seong Heo Health Hematology Hemostasis Hemostasis Today Immunotherapy In-Hyuk Jung Ingrid C. Rulifson Jixin Cui Johanna Diekmann Jose Barreda Junedh M. Amrute Kevin D. Cook Kory J. Lavine Medicine Melissa Thomas Nathan O. Stitziel Paul Cheng Rafael Kramann Roger S-Y Foo Scott Martin Sidrah Maryam Sikander Hayat Simon Jackson Steven Yang Thomas Quertermous Tracy Yamawaki Vishnu Chintalgattu Wen-Ling Lin Xianglong Zhang Xin Luo Yongjian Liu
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