Abhishek Paserkar։ Revolutionizing Hypertriglyceridemia Treatment With Olezarsen
Abhishek Paserkar, Medical Doctor, shared a post on LinkedIn:
՛՛Revolutionizing Hypertriglyceridemia Treatment!
Excited to dive into this groundbreaking review on Olezarsen (Tryngolza) – the next-gen GalNAc-conjugated antisense oligonucleotide targeting ApoC-III for severe hypertriglyceridemia and Familial Chylomicronemia Syndrome (FCS)!
Published in Cureus (Nov 2025) by Joshy et al., it highlights how olezarsen slashes triglycerides by ~60% in FCS patients over 12 months, dramatically cutting pancreatitis events (just 1 vs. 11 on placebo in BALANCE trial)!
Key Highlights
Mechanism Magic: Inhibits hepatic ApoC-III, boosting LPL-dependent and independent triglyceride clearance – even in LPL-deficient FCS!
Trial Triumphs: Phase 3 BALANCE: TG decreased 59%, ESSENCE: decreased 58-61% in moderate HTG + CV risk. Ongoing CORE trials target pancreatitis prevention in severe HTG.
Safety Superstar: Mild injection-site reactions only; no thrombocytopenia like older volanesorsen. Monthly 80mg SC dose – convenient and tolerable!
This precision therapy (FDA-approved Dec 2024) transforms management of life-threatening TG disorders, paving the way for CV risk reduction. A must-read for pharmacologists, endocrinologists and lipid experts! ՛՛
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