photo: ajmc.com
Feb 7, 2026, 15:24
Abeer Alanazi: Asundexian Reduces Stroke and Mortality Without Increased Bleeding
Abeer Alanazi, American Board Certified Pharmacotherapy Specialist and member at European Stroke Organisation (ESO), shared a post on LinkedIn.
“OCEANIC-STROKE
- Patients with non-cardioembolic ischemic stroke or TIA
- Concomitant dual antiplatelet therapy (DAPT)
- Asundexian initiated within 72 hours of symptom onset
- 6,162 patients received asundexian; 6,165 received placebo
- Treatment duration: 3–31 months
- 30% of patients had NIHSS >4
Efficacy
- Significant reduction in acute ischemic stroke (AIS)
- Significant reduction in cardiovascular mortality
- Significant reduction in all-cause mortality
Treatment effects were consistent across the overall population and all prespecified subgroups throughout the treatment period.
Safety
- No increase in major bleeding
- No increase in non-major bleeding
- No increase in symptomatic intracranial hemorrhage (sICH)
- No increase in hemorrhagic stroke
- No increase in fatal bleeding”

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