Alan Nurden: Angiodysplasia and Gastrointestinal Bleeding in Von Willebrand Disease
Alan Nurden, Emeritus Research Director at CNRS, Co-Founder of the French National Reference Centre for Inherited Platelet Disorders (CRPP), shared on LinkedIn about a recent article by Adela Constantinescu-Bercu et al, published in Blood:
“This online paper attacks an important problem, angiodysplasia and gastrointestinal (GI) bleeding in von Willebrand disease. The authors show a role for VWF in the secretion of angiopoietin-2 (angpt-2) from endothelial cells and alterations in the angpt-1/2 ratio at lesion sites in VWD-/- mice. Significantly, inhibition of angpt-2 normalized vascular remodeling in the mice.
From a personal point of view, I would like to see a similar study in the inherited platelet disorder, Glanzmann thrombasthenia (GT), where GI bleeding is also a terrible problem for a subset of patients. Platelets secrete angpt-1 and its role is considered anti-inflammatory.
It would be interesting to measure the angpt-1/2 ratio in GT patients with nor without angiodysplasia and to compare those whose gene defects affect ITGA2B (and are restricted to alphaIIbbeta3 in platelets), to those whose gene defects affect ITGB3 and extend to alphavbeta3, a purported target of angpt-2 in endothelial cells.”
Title: Von Willebrand Factor Deficiency Impairs Angiogenesis via Angiopoietin-2: Relevance for Gut Angiodysplasia
Authors: Adela Constantinescu-Bercu, Koval E Smith, Shuo Yi Wong, Mattia Ballerini, Alessia Nastro, Benjamin G Wiggins, Daniela Pirri, Yucheng Li, Juun Anora Maria Evers, Olga Tsiamita, Matthew Dibble, Charis Pericleous, Koralia E Paschalaki, Graeme M Birdsey, Jeremiah Bernier-Latmani, Tatiana V Petrova, Mike A Laffan, Suthesh Sivapalaratnam, Marco Rasponi, Anna M. Randi
Read the Full Article on Blood.
Stay updated on all scientific advances with Hemostasis Today.
-
Jul 7, 2026, 06:19Simone Schoenwaelder: Women Are 25% More Likely to Have Their Stroke Misdiagnosed and Here’s Why
-
Jul 7, 2026, 06:12Dhiraj Bhatia: Extremely Happy to Share Our Review on DNA Nanotechnology in Stroke Repair
-
Jul 7, 2026, 06:04Brian A Beh: An Open Letter to Lisa Murphy Honouring the 30 Years of the Stroke Foundation’s Dedication
-
Jul 7, 2026, 05:55Alan Nurden: A Landmark Review Comparing Hemophilia and Hereditary Angioedema
-
Jul 7, 2026, 05:40Andrew Agwunobi: UConn Health is Proud to Advance Stroke Rehabilitation for Veterans
-
Jul 6, 2026, 22:54Louise St. Germain Bannon: I Wanted to Recognize the Incredible Staff Behind ISTH 2026
-
Jul 6, 2026, 21:46Armghan Ans: UPMC Washington Stroke Program Earns AHA Gold Plus Award for 16th Consecutive Year
-
Jul 6, 2026, 20:31Manik Madaan: Master Transfusion Reactions for USMLE In Less Than 60 Seconds
-
Jul 6, 2026, 19:25Ambreen Kashif: Highlighting the Impact of Temporary Donor Deferrals on Donor Retention