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Emma Lefrancais: Uncovering A Key Role for The IL-33/ST2 Axis in Platelet Biology with Lucie Gelon
Emma Lefrancais ;Lucie Gelon/LinkedIn
Feb 23, 2026, 11:29

Emma Lefrancais: Uncovering A Key Role for The IL-33/ST2 Axis in Platelet Biology with Lucie Gelon

Emma Lefrancais, Scientific Researcher at CNRS, shared on LinkedIn about a recent article by Lucie Gelon et al, published in Blood Advances:

”I’m delighted to share the publication of Lucie Gelon PhD work, available online at Blood Advances, uncovering a key role for the IL-33/ST2 axis in platelet biology:

‘The alarmin Interleukin-33 modulates platelet proteome, function and biogenesis’

Although platelets do not express IL-33, our study shows that IL-33 profoundly shapes their production and function.

We demonstrate that IL-33/ST2 signaling:

  • remodels the platelet proteome, enriching inflammatory proteins
  • impairs platelet adhesion and thrombus formation when absent
  • accelerates platelet production in the lung by promoting megakaryocyte fragmentation within the vasculature

These mechanisms are likely to be particularly relevant during stress and aging, when IL-33–responsive megakaryocyte precursors expand.

Huge congratulations to Lucie Gelon for this great work at IPBS-Toulouse (CNRS-UT3), and many thanks to all co-authors and collaborators, Stéphane Roga, Jean-Philippe Girard, Anne Gonzalez de Peredo, Edith Vidal and Sonia Severin!”

Title: The alarmin Interleukin-33 modulates platelet proteome, function and biogenesis

Authors: Lucie Gelon, Stéphane Roga, Anne Gonzalez-de-Peredo, Edith Vidal, Jean-Philippe Girard, Sonia Severin, Emma Lefrançais

Read the Full Article on Blood Advances

Emma Lefrancais: Uncovering A Key Role for The IL-33/ST2 Axis in Platelet Biology with Lucie Gelon

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Anne Gonzalez-de-Peredo Edith Vidal Emma Lefrancais Health Hematology Hemostasis Hemostasis News Hemostasis Today IL-33 Jean-Philippe Girard Lucie Gelon Medicine platelets Sonia Severin Stéphane Roga thrombosis
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