Wolfgang Miesbach/LinkedIn
Feb 25, 2026, 12:36
Wolfgang Miesbach: Repurposing Metformin – From Sugar Control to Thrombus Control
Wolfgang Miesbach, Professor of Medicine at Frankfurt University Hospital, shared on LinkedIn:
”Repurposing Metformin: From Sugar Control to Thrombus Control
One of the many excellent posters at this year’s GTH 2026 meeting in Bonn was from the team in Düsseldorf, exploring an unexpected player in abdominal aortic aneurysm (AAA) therapy: the antidiabetic drug metformin.
Their work looks at how metformin modulates platelet activation and ex vivo thrombus formation in human whole blood – a fascinating angle, given the growing recognition that platelets and intraluminal thrombus are not just bystanders but active drivers of AAA progression:
- A ‘classic’ diabetes drug being repurposed to target vascular inflammation and thrombosis, in a disease area where truly effective pharmacological treatments are still lacking.
- Experimental data suggesting that metformin can inhibit platelet activation and arterial/venous thrombosis without prolonging bleeding time, by acting on mitochondrial pathways – hinting at a new, ‘metabolic’ form of antiplatelet therapy.
- Use of human samples and arterial‑shear thrombus assays keeps the model close to clinical reality and directly links cellular mechanisms to the thrombotic milieu observed in AAA.
- The concept that dampening platelet hyperreactivity might not only reduce thrombotic complications but also slow aneurysm expansion is particularly attractive and could complement ongoing clinical trials of metformin in AAA.”
Stay updated with Hemostasis Today.
-
Oct 20, 2026, 02:37M. Sekip Altunkan: Can Anticoagulation Be Safely Stopped After AF Ablation?
-
Oct 20, 2026, 02:26Ahmed Ammar: Managing VT Recurrence Post-Ablation
-
Oct 20, 2026, 01:43Oliver Weingärtner: Deprescribing of Lipid Lowering Drug after MI is Associated with Cardiovascular Events
-
Oct 19, 2026, 19:44Where You Live Should not Determine Whether You Receive Care – World Federation of Hemophilia
-
Oct 19, 2026, 19:42Belen Bianco: Prevention, Early Suspicion and an Interdisciplinary Approach Save Lives
-
Oct 19, 2026, 19:40Christina Chrysohoou: Catheter-Based LAAC vs OAC for Stroke Prevention in Atrial Fibrillation
-
Oct 19, 2026, 19:38Matthew Flick: A Two-Day Research Meeting on Fibrinogen, Hemostasis and Thrombosis
-
Oct 19, 2026, 19:37Hayat Saeed: Excited to Share Our Publication on the FGL1–Hepcidin Axis in Iron Homeostasis and Disease
-
Oct 19, 2026, 19:08IPAW 2026 Comes to a Close, but the Work Continues – PPTA