Deborah Siegal/LinkedIn
Mar 1, 2026, 10:31
Deborah Siegal Explores ARTESiA in The CLOT Conversation’s Latest Episode
Thrombosis Canada shared on LinkedIn:
”Major bleeding remains the leading complication of oral anticoagulation.
In our latest episode of CLOT Conversations, Dr. Deborah Siegal discusses the ARTESiA subanalysis examining major bleeding with apixaban versus aspirin in patients with device-detected subclinical atrial fibrillation.
Key insights:
- Apixaban reduced stroke/systemic embolism by 37%
- Major bleeding increased, largely driven by gastrointestinal events
- Intracranial and fatal bleeding rates were low and similar
- Most bleeding events were not clinical emergencies
- NSAID use emerged as a key modifiable risk factor
Understanding not just how often bleeding occurs, but how severe it is, is critical to individualized risk assessment and shared decision-making.”
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