Hemostasis Today

March, 2026
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Isabelle Mahé: Bleeding Risk Differs Across Solid Tumours in Cancer-Associated Thrombosis
Mar 14, 2026, 13:44

Isabelle Mahé: Bleeding Risk Differs Across Solid Tumours in Cancer-Associated Thrombosis

Isabelle Mahé, Head of Internal Medicine at the Louis Mourier Hospital, APHP at Paris Cité University, shared a post on LinkedIn about several recent articles she and her colleagues co-authored, adding:

“Another way to express that bleeding risk varies according to solid cancer site, with a low risk of CRB in breast cancer (6·2%) and a narrow range across other solid tumours (15·4–18·5%) (shown in figure 1 of the original Article recently published in The Lancet Haematology

Please read our reply just published in The Lancet Haematology!

In patients with CAT, reduced-dose apixaban is non inferior to full dose apixaban, and is associated with a significant 25% reduction in the risk of Clinically Relevant Bleeding (published in NEJM Group)”

Title 1: Predictors of clinically relevant bleeding during extended anticoagulation for cancer-associated venous thromboembolism (API-CAT): a post-hoc analysis of a randomised, non-inferiority trial

Authors: Isabelle Mahé, Céline Chapelle, Philippe Girard, Marc Carrier, Luis Jara Palomares, Charles-Marc Samama, Hélène Helfer, Grigoris Gerotziafas, Silvy Laporte, Eric Vicaut, Patrick Mismetti

Read the Full Article on The Lancet Haematology

Isabelle Mahé

Title 2: Predictors of clinically relevant bleeding during extended anticoagulation for cancer-associated VTE – Authors’ reply

Authors: Isabelle Mahé, Céline Chapelle, Silvy Laporte

Read the Full Article on The Lancet Haematology

Isabelle Mahé

Title 3: Extended Reduced-Dose Apixaban for Cancer-Associated Venous Thromboembolism

Authors: Isabelle Mahé, Marc Carrier, Didier Mayeur, Jean Chidiac, Eric Vicaut, Nicolas Falvo, Olivier Sanchez, Claire Grange, Manuel Monreal, Juan J. López-Núñez, Remedios Otero-Candelera, Grégoire Le Gal, Erik Yeo, Marc Righini, Helia Robert-Ebadi, Menno V. Huisman, Frederikus A. Klok, Peter Westerweel, Giancarlo Agnelli, Cecilia Becattini, Aristotelis Bamias, Kostas Syrigos, Sebastian Szmit, Adam Torbicki, Peter Verhamme, Anthony Maraveyas, Alexander T. Cohen, Cihan Ay, Céline Chapelle, Guy Meyer, Francis Couturaud, Patrick Mismetti, Philippe Girard, Laurent Bertoletti, Silvy Laporte

Read the Full Article on The New England Journal of Medicine

Isabelle Mahé

Faizan Khan, CIHR Banting Postdoctoral Fellow at University of Calgary, shared on LinkedIn about a recent article he and Nick van Es co-authored, adding:

”In a new publication from my Banting Canada postdoctoral fellowship out today in The Lancet Haematology, Nick van Es and I highlight the importance of considering different cancer sites for bleeding risk stratification in patients with cancer-associated Venous Thromboembolism.”

Title: Predictors of clinically relevant bleeding during extended anticoagulation for cancer-associated VTE

Authors: Faizan Khan, Nick van Es

Read the Full Article on The Lancet Haematology

Isabelle Mahé

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