Suvro Sankha Datta: IVIG-Induced Hemolysis and the Role of ABO Antibodies
Suvro Sankha Datta, Senior Consultant and Head Transfusion Medicine at Tata Medical Center, shared on LinkedIn about a recent article he and his colleagues co-authored, adding:
“IVIG is generally considered a safe product.
However, IVIG-induced hemolysis is increasingly reported in non-O blood group patients, particularly in children and in the presence of underlying inflammatory conditions.
IVIG contains ABO antibodies (IgG2 type), but the level of ABO antibodies is not provided by manufacturers, which should be below 1:64 according to the international guidelines.
The standard hemagglutination technique is not suitable for ABO antibody estimation in IVIG; therefore, the new bead-based glycan assay measuring ABO antibodies, including their subclasses, should be used as part of manufacturer quality control for commercially available IVIG products. The final titer value should be displayed over the product label.”
Title: Impact of ABO antibody components in Intravenous Immunoglobulin products on transfusion decision-making for patients following autologous stem cell transplantation
Authors: Najla Haneefa Basheela, Aniruddha Hazra, Durba Biswas, Debapriya Basu, Suvro Sankha Datta
Read the Full Article on Indian Journal of Hematology and Blood Transfusion
Stay updated with Hemostasis Today.
-
Sep 30, 2026, 01:52Javed Anees: DADA2 – When a Young Stroke Is More Than a Stroke
-
Sep 30, 2026, 01:51How a Venous Thrombus Becomes Revascularized – ISTH
-
Sep 29, 2026, 22:45Victor Agunyego: Paracetamol – The Most Common Drug We Underestimate
-
Sep 29, 2026, 22:42Nova Sinclair: Advancing the Future of Hematology – Meet Our 2027 Organizing Committee
-
Sep 29, 2026, 22:41Lorenz Räber: Intracoronary Imaging in PCI – Why, When, How, and Which Modality?
-
Sep 29, 2026, 22:31Selma Turkovic: Pleased to Deliver the Opening Presentation at Kingston Hospital
-
Sep 29, 2026, 22:31Miguel Teran: Ultrasound and Simulation in Arterial Blood Sampling
-
Sep 29, 2026, 22:28Mohammad Refaei: Navigating Your Career in Hematology From Training to Practice
-
Sep 29, 2026, 22:27Matteo Foschi: 10 Clinical Pearls for Antithrombotic Therapy in Secondary Stroke Prevention