Jagadeesh Bayry: Molecular and Genetic Mechanisms of VITT
Jagadeesh Bayry, Professor and Head of Department at the Indian Institute of Technology Palakkad, shared a post on LinkedIn and about a recent article he and his colleagues co-authored, adding:
“An editorial commentary in Nature Reviews Cardiology, Nature Portfolio, co-authored with Julie Rayes, discusses the mechanisms underlying Vaccine-induced immune thrombotic thrombocytopenia, a rare complication of adenoviral vector-based COVID-19 vaccines.
An elegant study by the groups of J. J. Wang and Andreas Greinacher demonstrates that VITT arises from molecular mimicry between platelet factor 4 PF4 and adenoviral core protein VII.
In genetically predisposed individuals carrying IGLV3-21 star 02 or star 03 alleles, a key somatic mutation K31E in the IgG light chain redirects antiviral immunity toward pathogenic anti PF4 responses, triggering platelet activation and thrombosis.
This work provides a compelling example of how genetic background and somatic hypermutation converge to drive autoimmunity, and opens new avenues for designing safer adenoviral vector platforms.”
Title: Solving the mystery of vaccine-induced immune thrombocytopenia and thrombosis
Authors: Julie Rayes, Jagadeesh Bayry
Read the Full Article on Nature Reviews Cardiology.
Title: Adenoviral Inciting Antigen and Somatic Hypermutation in VITT
Authors: Jing Jing Wang, Linda Schönborn, Theodore E. Warkentin, Luisa Müller, Thomas Thiele, Lena Ulm, Uwe Völker, Sabine Ameling, Sören Franzenburg, Lars Kaderali, Ana Tzvetkova, Alex Colella, Tim Chataway, Chee Wee Tan, Bridie Armour, Alexander Troelnikov, Lucy Rutten, James McCluskey, Roland Zahn, Tom P. Gordon, Andreas Greinacher
Read the Full Article on The New England Journal Of Medicine.
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