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ABO-Incompatible Transfusions and Severe Allergic Reactions – ISBT
Image/Vox Sanguinis
Mar 25, 2026, 15:35

ABO-Incompatible Transfusions and Severe Allergic Reactions – ISBT

International Society of Blood Transfusion (ISBT) shared a post on LinkedIn about a recent article by Lucile Malard et al. published in Vox Sanguinis:

“Recently published in Vox Sanguinis

Association between group B major ABO-incompatible platelet or plasma transfusion and severe allergic reactions: A nationwide haemovigilance analysis suggesting a role for α-gal syndrome.

Key takeaways:

  • Transfusing group B or AB platelets/plasma to group O recipients in France is linked to higher risk of severe allergic transfusion reactions (ATR).
  • The risk is stronger with platelet transfusions than plasma, possibly related to α-gal syndrome.
  • Recommendation: Group O recipients should receive ABO-identical platelets or plasma whenever possible.

A step forward in safer, personalized transfusion care.”

Title: Association between group B major ABO-incompatible platelet or plasma transfusion and severe allergic reactions: A nationwide haemovigilance analysis suggesting a role for α-gal syndrome. A Biomedical Excellence for Safer Transfusion Collaborative study

Authors: Lucile Malard, Cléo Beuscart, Luc de Chaisemartin, Virginie de La Taille, Catherine Humbrecht, Syria Laperche, Pierre Tiberghien

Read the Full Article on Vox Sanguinus Journal

ABO-Incompatible Transfusions and Severe Allergic Reactions - ISBT

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Catherine Humbrecht Cléo Beuscart e International Society of Blood Transfusion (ISBT) International Society of Blood Transfusion (ISBT) Luc de Chaisemartin Lucile Malard Pierre Tiberghien Syria Laperche Virginie de La Taille
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