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ChAdOx1 and Shear‑Dependent Platelet Aggregation: Uncovering a New Thrombotic Pathway
Jul 28, 2025, 12:04

ChAdOx1 and Shear‑Dependent Platelet Aggregation: Uncovering a New Thrombotic Pathway

The Blood Journals Portfolio reported on its official X:

ChAdOx1 induces platelet aggregation under shear via biomechanically activated integrin αIIbβ3, bypassing GPIb-dependent platelet adhesion pathway.”

Title: Shear-dependent platelet aggregation by ChAdOx1 nCoV-19 vaccine: a novel biophysical mechanism for arterial thrombosis

Authors: Yiyao Catherine Chen, Naveen Eugene Louis Richard Louis, Angela Huang, Allan Sun, Alexander Dupuy, Laura Moldovan, Tiana Pelaia, Jianfang Ren, Taylor S. Cohen, Sarah C. Gilbert, Huyen Tran, Karlheinz Peter, James D. McFadyen, Lining Arnold Ju

ChAdOx1 and Shear‑Dependent Platelet Aggregation: Uncovering a New Thrombotic Pathway

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