Nathan Connell: How the 2021 VWD Guidelines Are Actually Changing Real – World Practice
Nathan Connell, Clinical Chief of Hematology at Brigham and Women’s Faulkner Hospital, shared a post on LinkedIn about a recent article by Michael Dong et al, published in Haemophilia:
“It’s encouraging to see centers beginning to evaluate how the 2021 von Willebrand disease guidelines are actually changing real-world practice.
This study, published in Haemophilia Journal, examines the impact of the ASH, ISTH, NHF, WFH 2021 guideline diagnostic criteria on patients with ‘low VWF’ in a single – center cohort. The authors, from the Gulf States Hemophilia and Thrombophilia Center in Houston, demonstrated that almost 75 percent of encounters were reclassified from ‘low VWF’ to type 1 VWD when bleeding phenotype was incorporated.
This reclassification led to increased use of VWF therapy and antifibrinolytics, and more than half of patients showed rising VWF levels with age, reinforcing the need for longitudinal reassessment.
Importantly, bleeding phenotypes were broadly similar between ‘low VWF’ and traditional type 1 VWD, supporting the rationale behind the guideline shift.
It is great to see clinical programs moving beyond guideline publication to actually assessing impact within their own patient populations.
That feedback loop is essential if we want guidelines to improve care meaningfully.”
Title: Assessing the Impact of the 2021 VWD Guidelines on the Diagnosis/Management of Low VWF Patients
Authors: Michael Dong, Joanna Larson, Sepideh Saroukhani, Miguel Escobar, Lakshmi Srivaths
Read the Full Article on Haemophilia
Other posts featuring Nathan Connell on Hemostasis Today.
-
Jul 7, 2026, 06:19Simone Schoenwaelder: Women Are 25% More Likely to Have Their Stroke Misdiagnosed and Here’s Why
-
Jul 7, 2026, 06:12Dhiraj Bhatia: Extremely Happy to Share Our Review on DNA Nanotechnology in Stroke Repair
-
Jul 7, 2026, 06:04Brian A Beh: An Open Letter to Lisa Murphy Honouring the 30 Years of the Stroke Foundation’s Dedication
-
Jul 7, 2026, 05:55Alan Nurden: A Landmark Review Comparing Hemophilia and Hereditary Angioedema
-
Jul 7, 2026, 05:40Andrew Agwunobi: UConn Health is Proud to Advance Stroke Rehabilitation for Veterans
-
Jul 6, 2026, 22:54Louise St. Germain Bannon: I Wanted to Recognize the Incredible Staff Behind ISTH 2026
-
Jul 6, 2026, 21:46Armghan Ans: UPMC Washington Stroke Program Earns AHA Gold Plus Award for 16th Consecutive Year
-
Jul 6, 2026, 20:31Manik Madaan: Master Transfusion Reactions for USMLE In Less Than 60 Seconds
-
Jul 6, 2026, 19:25Ambreen Kashif: Highlighting the Impact of Temporary Donor Deferrals on Donor Retention