Are We Underestimating VTE After PanNET Surgery? – RPTH Journal
RPTH Journal shared a post on LinkedIn about a recent article by Kelly Dong et al:
”Postoperative VTE in pancreatic neuroendocrine tumors. Are we underestimating risk?
A large NSQIP analysis (n=60,649) examined VTE after pancreatectomy for pNENs vs other histologies.
Key findings:
- Overall VTE risk is similar to other pancreatic cancers (approximately 3.6%)
- But DVT risk is higher in pNEN vs PDAC (adjusted OR approximately 1.25)
- PE risk is not significantly different
What drives VTE in pNEN?
Independent risk factors include:
- Increased BMI
- Pre-op transfusion
- Longer operative tim
- Total pancreatectomy
- Longer hospital stay
Interpretation:
Despite being perceived as ‘less aggressive’ tumors, pNEN patients carry a meaningful thrombotic burden, particularly for DVT.
This is clinically important because:
- Guidelines for extended prophylaxis in pNEN are unclear
- Tumor heterogeneity may mask high-risk subgroups
- Surgical complexity still drives thrombosis risk”
Title: Venous thromboembolism following surgery for pancreatic neuroendocrine neoplasms
Authors: Kelly Dong, Yasmin Essaji, Caitlin W. Hicks, Elliott R. Haut, Michail N. Mavros
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