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Xiaoying Chen: Rethinking Thrombectomy in Large-Core Stroke – Insights from LASTE Analysis
Xiaoying Chen/LinkedIn
Apr 21, 2026, 11:42

Xiaoying Chen: Rethinking Thrombectomy in Large-Core Stroke – Insights from LASTE Analysis

Xiaoying Chen, Senior Research Fellow at The George Institute for Global Health, shared on LinkedIn about a recent article by Bertrand Lapergue et al, published in Stroke, adding:

”One of the hardest questions in acute stroke is how far we can safely extend reperfusion treatment in patients with very large established infarcts.

This secondary analysis from LASTE suggests that even patients with ASPECTS 0–2 should not be treated as a uniformly futile group, with signals for better outcomes and lower mortality after thrombectomy.

From my perspective, this is exactly where modern stroke trials need to go next: not broad over-simplifications of ‘large core’ stroke, but smarter subgroup learning that can identify where benefit persists, where bleeding risk rises, and how more precise treatment decisions can be made in real-world practice.”

Title: Endovascular Thrombectomy in Patients With Largest Baseline Infarcts (ASPECTS 0–2): An Ancillary Analysis of the LASTE Trial

Authors: Bertrand Lapergue, Caroline Arquizan, J.F. Albucher, Christophe Cognard, Hilde Henon, Nasreddine Nouri, Benjamin Gory, Sebastien Richard, Gauthier Marnat, Igor Sibon, Federico Di Maria, Mariam Annan, Grégoire Boulouis, Pere Cardona, Julien Labreuche, Vincent Costalat, Tudor Jovin

Xiaoying Chen: Rethinking Thrombectomy in Large-Core Stroke - Insights from LASTE Analysis

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Benjamin Gory Bertrand Lapergue Caroline Arquizan Christophe Cognard endovascular thrombectomy Federico Di Maria Gauthier Marnat Grégoire Boulouis Health Hematology Hemostasis Hemostasis News Hemostasis Today Hilde Henon Igor Sibon J.F. Albucher Julien Labreuche LASTE Mariam Annan Medicine Mortality Nasreddine Nouri Pere Cardona Sebastien Richard stroke thrombosis Tudor Jovin Vincent Costalat Xiaoying Chen
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