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Abdul Mannan: The Clinical Pattern That Should Make You Think of VEXAS
Abdul Mannan/LinkedIn
Apr 30, 2026, 14:33

Abdul Mannan: The Clinical Pattern That Should Make You Think of VEXAS

Abdul Mannan, Consultant Haematologist at Betsi Cadwaladr University Health Board, shared a post on LinkedIn:

“VEXAS Series – 3 LinkedIn Posts

POST 1 of 3 – VEXAS: The Big Picture

An older man. Fever. Ear chondritis. Macrocytic anaemia. Cytopenia.

Rheumatology refers him to haematology.

Haematology refers him back.

Everyone is partly right. No one has the full answer.

Until you look at his bone marrow.

That’s VEXAS. And it’s sitting in your clinic right now.

VEXAS stands for:

  • Vacuoles
  • E1 enzyme
  • X-linked
  • Autoinflammatory
  • Somatic

It’s caused by a somatic mutation in the UBA1 gene – the gene that runs the ubiquitin system, the cell’s own protein clean-up mechanism.

When UBA1 fails, cells accumulate stress.

Inflammation ignites.

And the bone marrow starts showing visible damage.

Here’s what to look for clinically:

  • Fever and recurrent systemic inflammation
  • Chondritis — ears and nose
  • Skin lesions
  • Eye involvement
  • Lung disease
  • Macrocytic anaemia with low WBC and/or platelets

And on the bone marrow:

  • Vacuoles in early neutrophil precursors
  • Vacuoles in early erythroid precursors

One thing every haematologist must know: vacuoles are suggestive, not diagnostic.

MDS, copper deficiency, alcohol excess, malnutrition, and active inflammation can all produce the same picture.

The clinical signal is this: older adult plus inflammation plus cytopenia plus macrocytosis plus vacuolated marrow precursors.

Confirm with UBA1 testing.

This is Part 1 of my 3-part VEXAS series.

Tomorrow: how to use marrow morphology as a practical triage tool.

Have you diagnosed VEXAS in your centre? I’d love to hear your experience.”

Abdul Mannan: The Clinical Pattern That Should Make You Think of VEXAS

Other posts from Abdul Mannan on Hemostasis Today.

(inflammation Abdul Mannan Anaemia bleeding disorders bone marrow Health Hematology Hemostasis Hemostasis News Hemostasis Today leukopenia Medicine UBA1 gene Vexas
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